OBJECTIVE: To evaluate whether obesity and smoking habit may accelerate the age-related increase of oxidative stress. METHODS: The Oxidative-INDEX, a score reflecting both oxidative and antioxidant counterparts, was estimated in 179 subjects (50 males, aged 16-79 years). RESULTS: Oxidative stress results were elevated in obese and smoker subjects. Adjusted logistic regression analysis indicated obesity and smoking as independent variables for elevated Oxidative-INDEX (odds ratio=4.8 and 3.1, respectively). Oxidative-INDEX steadily rises at a mean rate of 5.3% (0.017 AU) per year in the overall population, showing twice and three times higher annual rate increase in smokers and obese subjects. CONCLUSION: Our results suggest the pro-ageing effects of cigarette smoking and obesity by a more rapid and sharp elevation of the oxidative stress status.
OBJECTIVE: To evaluate whether obesity and smoking habit may accelerate the age-related increase of oxidative stress. METHODS: The Oxidative-INDEX, a score reflecting both oxidative and antioxidant counterparts, was estimated in 179 subjects (50 males, aged 16-79 years). RESULTS: Oxidative stress results were elevated in obese and smoker subjects. Adjusted logistic regression analysis indicated obesity and smoking as independent variables for elevated Oxidative-INDEX (odds ratio=4.8 and 3.1, respectively). Oxidative-INDEX steadily rises at a mean rate of 5.3% (0.017 AU) per year in the overall population, showing twice and three times higher annual rate increase in smokers and obese subjects. CONCLUSION: Our results suggest the pro-ageing effects of cigarette smoking and obesity by a more rapid and sharp elevation of the oxidative stress status.
Authors: Ann Bremander; Lennart T H Jacobsson; Stefan Bergman; Emma Haglund; Sofia Löfvendahl; Ingemar F Petersson Journal: Clin Rheumatol Date: 2014-07-15 Impact factor: 2.980
Authors: Marco Aurélio Echart Montano; Juan Pablo Barrio Lera; Maria Gabriela Valle Gottlieb; Carla Helena Augustin Schwanke; Maria Izabel Ugalde Marques da Rocha; Maria Fernanda Manica-Cattani; Greice Feyl dos Santos; Ivana Beatrice Manica da Cruz Journal: Mol Cell Biochem Date: 2009-03-05 Impact factor: 3.396