Literature DB >> 19100831

The molecular mechanism and cellular functions of mitochondrial division.

Laura L Lackner1, Jodi M Nunnari.   

Abstract

Mitochondria are highly dynamic organelles that continuously divide and fuse. These dynamic processes regulate the size, shape, and distribution of the mitochondrial network. In addition, mitochondrial division and fusion play critical roles in cell physiology. This review will focus on the dynamic process of mitochondrial division, which is highly conserved from yeast to humans. We will discuss what is known about how the essential components of the division machinery function to mediate mitochondrial division and then focus on proteins that have been implicated in division but whose functions remain unclear. We will then briefly discuss the cellular functions of mitochondrial division and the problems that arise when division is disrupted.

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Year:  2008        PMID： 19100831      PMCID： PMC4076010          DOI： 10.1016/j.bbadis.2008.11.011

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  100 in total

1.  Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission.

Authors:  Zdena Harder; Rodolfo Zunino; Heidi McBride
Journal:  Curr Biol       Date:  2004-02-17       Impact factor: 10.834

2.  SH3GLB, a new endophilin-related protein family featuring an SH3 domain.

Authors:  B Pierrat; M Simonen; M Cueto; J Mestan; P Ferrigno; J Heim
Journal:  Genomics       Date:  2001-01-15       Impact factor: 5.736

Review 3.  Yeast mitochondrial dynamics: fusion, division, segregation, and shape.

Authors:  R E Jensen; A E Hobbs; K L Cerveny; H Sesaki
Journal:  Microsc Res Tech       Date:  2000-12-15       Impact factor: 2.769

Review 4.  Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria.

Authors:  J Bereiter-Hahn; M Vöth
Journal:  Microsc Res Tech       Date:  1994-02-15       Impact factor: 2.769

5.  Division of mitochondria requires a novel DNM1-interacting protein, Net2p.

Authors:  K L Cerveny; J M McCaffery; R E Jensen
Journal:  Mol Biol Cell       Date:  2001-02       Impact factor: 4.138

6.  Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology.

Authors:  Diana Stojanovski; Olga S Koutsopoulos; Koji Okamoto; Michael T Ryan
Journal:  J Cell Sci       Date:  2004-03-01       Impact factor: 5.285

7.  Nuclear migration in Saccharomyces cerevisiae is controlled by the highly repetitive 313 kDa NUM1 protein.

Authors:  J Kormanec; I Schaaff-Gerstenschläger; F K Zimmermann; D Perecko; H Küntzel
Journal:  Mol Gen Genet       Date:  1991-11

8.  Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p.

Authors:  A D Mozdy; J M McCaffery; J M Shaw
Journal:  J Cell Biol       Date:  2000-10-16       Impact factor: 10.539

9.  Cortical Num1p interacts with the dynein intermediate chain Pac11p and cytoplasmic microtubules in budding yeast.

Authors:  M Farkasovsky; H Küntzel
Journal:  J Cell Biol       Date:  2001-01-22       Impact factor: 10.539

10.  Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division.

Authors:  Q Tieu; J Nunnari
Journal:  J Cell Biol       Date:  2000-10-16       Impact factor: 10.539
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  61 in total

Review 1.  Mitochondrial fission and fusion.

Authors:  Iain Scott; Richard J Youle
Journal:  Essays Biochem       Date:  2010       Impact factor: 8.000

Review 2.  Mechanisms of mitochondria and autophagy crosstalk.

Authors:  Angelika S Rambold; Jennifer Lippincott-Schwartz
Journal:  Cell Cycle       Date:  2011-12-01       Impact factor: 4.534

3.  A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells.

Authors:  Jinhua Shen; Xia Liu; Wen-Mei Yu; Jie Liu; Milou Groot Nibbelink; Caiying Guo; Toren Finkel; Cheng-Kui Qu
Journal:  Mol Cell Biol       Date:  2011-10-10       Impact factor: 4.272

Review 4.  New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics.

Authors:  Stephane G Rolland; Barbara Conradt
Journal:  Curr Opin Cell Biol       Date:  2010-08-20       Impact factor: 8.382

Review 5.  Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1.

Authors:  Chuang-Rung Chang; Craig Blackstone
Journal:  Ann N Y Acad Sci       Date:  2010-07       Impact factor: 5.691

Review 6.  The axonal transport of mitochondria.

Authors:  William M Saxton; Peter J Hollenbeck
Journal:  J Cell Sci       Date:  2012-05-22       Impact factor: 5.285

7.  Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion.

Authors:  Stéphane G Rolland; Elisa Motori; Nadin Memar; Jürgen Hench; Stephan Frank; Konstanze F Winklhofer; Barbara Conradt
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-22       Impact factor: 11.205

8.  DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons.

Authors:  Anna Santoro; Michela Campolo; Chen Liu; Hiromi Sesaki; Rosaria Meli; Zhong-Wu Liu; Jung Dae Kim; Sabrina Diano
Journal:  Cell Metab       Date:  2017-02-09       Impact factor: 27.287

9.  Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis.

Authors:  F Rossin; M D'Eletto; L Falasca; S Sepe; S Cocco; G M Fimia; M Campanella; P G Mastroberardino; M G Farrace; M Piacentini
Journal:  Cell Death Differ       Date:  2014-07-25       Impact factor: 15.828

10.  CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death.

Authors:  Arezu Jahani-Asl; En Huang; Isabella Irrcher; Juliet Rashidian; Naotada Ishihara; Diane C Lagace; Ruth S Slack; David S Park
Journal:  Hum Mol Genet       Date:  2015-05-22       Impact factor: 6.150
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