| Literature DB >> 19100738 |
Yukiko Kaneko1, Toshihide Kimura, Shigeki Taniguchi, Midori Souma, Yumiko Kojima, Yuka Kimura, Hideo Kimura, Ichiro Niki.
Abstract
We examined the expression of the major H(2)S-producing enzymes, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE). CBS was ubiquitously distributed in the mouse pancreas, but CSE was found only in the exocrine. Freshly isolated islets expressed CBS, while CSE was faint. However, high glucose increased the CSE expression in the beta-cells. L-Cysteine or NaHS suppressed islet cell apoptosis with high glucose, and increased glutathione content in MIN6 beta-cells. Pretreatment with L-cysteine improved the secretory responsiveness following stimulation with glucose. The CSE inhibitor DL-propargylglycine antagonized these L-cysteine effects. We suggest H(2)S may function as an 'intrinsic brake' which protects beta-cells from glucotoxicity.Entities:
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Year: 2008 PMID： 19100738 DOI： 10.1016/j.febslet.2008.12.026
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124