| Literature DB >> 19100397 |
B Tanriover1, S E Wright, S V Foster, K S Roush, J A Castillo-Lugo, K Fa, F L Levy, A Mejia.
Abstract
Antibody-mediated rejection (AMR) generally occurs in highly sensitized patients. A pilot study was performed on 7 consecutive patients with AMR to assess the efficacy of high-dose intravenous immunoglobulin (IVIG; 2 g/kg) + rituximab (RTX; 375 mg/m(2)) without plasmapheresis. After a 24-month follow-up, 1- and 2-year allograft survivals were 86% and 58%, respectively. C4d became negative in 1 patient posttreatment. Donor-specific antibody (DSA) titers decreased to less than 1:4 in 2 cases. There were 4 infectious complications and 1 case of aseptic meningitis followed by cranial nerve VI palsy. The average hospital charge for 1 administration of IVIG + RTX, including hospital stay and renal biopsy expenses, was approximately $49,000. A combination of IVIG + RTX in late AMR may be beneficial but is an expensive treatment approach for selected renal transplant patients.Entities:
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Year: 2008 PMID： 19100397 DOI： 10.1016/j.transproceed.2008.08.131
Source DB: PubMed Journal: Transplant Proc ISSN： 0041-1345 Impact factor: 1.066