Literature DB >> 19100320

Particle size control of poly(dl-lactide-co-glycolide) nanospheres for sterile applications.

Yusuke Tsukada1, Kaori Hara, Yohei Bando, C C Huang, Yasuo Kousaka, Yoshiaki Kawashima, Ryuichi Morishita, Hiroyuki Tsujimoto.   

Abstract

Parameters affecting the particle sizes of poly(DL-lactide-co-glycolide) (PLGA) nanospheres produced by the Emulsion Solvent Diffusion (ESD) method were evaluated in this study, so that suitable PLGA nanospheres could be prepared to pass through a membrane filter with 0.2 microm pore size and used as a sterile product. Experimental results demonstrated that the particle sizes of PLGA nanospheres could be reduced by the following efforts. (1) Increase stirring rate of poor solvent. (2) Decrease feed rate of good solvent. (3) Increase poor solvent ratio. (4) Increase the temperature of poor solvent. (5) Decrease polyvinyl alcohol concentration in poor solvent. (6) Increase ethanol concentration in good solvent. (7) Decrease PLGA concentration in good solvent. After optimization, PLGA nanospheres with a mean particle size of 102-163 nm and the 100-98% of filtration fraction could be produced and passed the bacteria challenge tests. This study found PLGA nanospheres can be efficiently prepared as a sterile product.

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Year:  2008        PMID： 19100320     DOI： 10.1016/j.ijpharm.2008.11.019

Source DB:  PubMed          Journal:  Int J Pharm        ISSN： 0378-5173            Impact factor:   5.875


  7 in total

1.  Development of PLGA-PEG-COOH and gelatin-based microparticles dual delivery system and E-beam sterilization effects for controlled release of BMP-2 and IGF-1.

Authors:  Yan Bai; Seyedsina Moeinzadeh; Sungwoo Kim; Youngbum Park; Elaine Lui; Hua Tan; Weiling Zhao; Xiaobo Zhou; Yunzhi Peter Yang
Journal:  Part Part Syst Charact       Date:  2020-08-18       Impact factor: 3.310

Review 2.  Materials for pharmaceutical dosage forms: molecular pharmaceutics and controlled release drug delivery aspects.

Authors:  Heidi M Mansour; Minji Sohn; Abeer Al-Ghananeem; Patrick P Deluca
Journal:  Int J Mol Sci       Date:  2010-09-15       Impact factor: 5.923

3.  Continuous in-line homogenization process for scale-up production of naltrexone-loaded PLGA microparticles.

Authors:  Farrokh Sharifi; Andrew Otte; Gwangheum Yoon; Kinam Park
Journal:  J Control Release       Date:  2020-07-07       Impact factor: 11.467

4.  Multifunctional polymeric nanoparticles doubly loaded with SPION and ceftiofur retain their physical and biological properties.

Authors:  Paula Solar; Guillermo González; Cristian Vilos; Natalia Herrera; Natalia Juica; Mabel Moreno; Felipe Simon; Luis Velásquez
Journal:  J Nanobiotechnology       Date:  2015-02-13       Impact factor: 10.435

5.  Intravenous Administration of Cilostazol Nanoparticles Ameliorates Acute Ischemic Stroke in a Cerebral Ischemia/Reperfusion-Induced Injury Model.

Authors:  Noriaki Nagai; Chiaki Yoshioka; Yoshimasa Ito; Yoshinori Funakami; Hiroyuki Nishikawa; Atsufumi Kawabata
Journal:  Int J Mol Sci       Date:  2015-12-09       Impact factor: 5.923

6.  Preparation of Microcrystals of Piroxicam Monohydrate by Antisolvent Precipitation via Microfabricated Metallic Membranes with Ordered Pore Arrays.

Authors:  Rahimah Othman; Goran T Vladisavljević; Elena Simone; Zoltan K Nagy; Richard G Holdich
Journal:  Cryst Growth Des       Date:  2017-11-13       Impact factor: 4.076

7.  Silymarin-loaded solid nanoparticles provide excellent hepatic protection: physicochemical characterization and in vivo evaluation.

Authors:  Kwan Yeol Yang; Du Hyeong Hwang; Abid Mehmood Yousaf; Dong Wuk Kim; Young-Jun Shin; Ok-Nam Bae; Yong-Il Kim; Jong Oh Kim; Chul Soon Yong; Han-Gon Choi
Journal:  Int J Nanomedicine       Date:  2013-08-28
  7 in total

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