OBJECTIVE: To investigate the diagnostic value of the tissue strain imaging in myocardial dysfunction in children with systemic lupus erythematosus (SLE). METHODS: 24 patients with SLE and 32 healthy controls underwent conventional and tissue Doppler echocardiography. Peak strain and strain rate value during systolic and diastolic phases as well as E/A, LVFS, LVEF were measured in both SLE and the control group subjects. RESULTS: The E/A, LVFS and LVEF did not significantly differ between SLE children and controls (P > 0.05). The systolic peak strains and strain rates of SLE children were lower than those of the controls but there was no significant difference (P > 0.05). The diastolic peak strains and strain rates of SLE children were significantly lower than those of the controls (P < 0.01). The diastolic peak strains and strain rates of anticardiolipin antibodies (aCL) positive children were significantly lower than the aCL negative ones (P < 0.05). CONCLUSION: Strain and strain rate combined with aCL could sensitively detect myocardial dysfunction of children with SLE.
OBJECTIVE: To investigate the diagnostic value of the tissue strain imaging in myocardial dysfunction in children with systemic lupus erythematosus (SLE). METHODS: 24 patients with SLE and 32 healthy controls underwent conventional and tissue Doppler echocardiography. Peak strain and strain rate value during systolic and diastolic phases as well as E/A, LVFS, LVEF were measured in both SLE and the control group subjects. RESULTS: The E/A, LVFS and LVEF did not significantly differ between SLEchildren and controls (P > 0.05). The systolic peak strains and strain rates of SLEchildren were lower than those of the controls but there was no significant difference (P > 0.05). The diastolic peak strains and strain rates of SLEchildren were significantly lower than those of the controls (P < 0.01). The diastolic peak strains and strain rates of anticardiolipin antibodies (aCL) positive children were significantly lower than the aCL negative ones (P < 0.05). CONCLUSION: Strain and strain rate combined with aCL could sensitively detect myocardial dysfunction of children with SLE.