Literature DB >> 1909972

A novel brain-specific 25 kDa protein (p25) is phosphorylated by a Ser/Thr-Pro kinase (TPK II) from tau protein kinase fractions.

M Takahashi1, K Tomizawa, K Ishiguro, K Sato, A Omori, S Sato, A Shiratsuchi, T Uchida, K Imahori.   

Abstract

A novel brain-specific 25 kDa protein (p25) was purified from a bovine brain extract. The protein was phosphorylated by Ser/Thr-Pro kinase (TPK II) in tau protein kinase fractions at the Ser residues of Ser-Pro sequences. Using immunoblot analysis, the protein was found only in brain extracts, and was most abundant in the brain regions such as cerebrum and hippocampus, but less abundant in cerebellum, medulla oblongata and olfactory bulb. The protein was detected in rat, bovine and human brain extracts, indicating that this protein specifically exists in mammalian brain tissues.

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Year:  1991        PMID： 1909972     DOI： 10.1016/0014-5793(91)80903-g

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  16 in total

Review 1.  Functional aspects of cellular microcompartmentation in the development of neurodegeneration: mutation induced aberrant protein-protein associations.

Authors:  Judit Ovádi; Ferenc Orosz; Susan Hollán
Journal:  Mol Cell Biochem       Date:  2004 Jan-Feb       Impact factor: 3.396

2.  p25alpha is flexible but natively folded and binds tubulin with oligomeric stoichiometry.

Authors:  Daniel E Otzen; Ditte M S Lundvig; Reinhard Wimmer; Lotte H Nielsen; Jakob R Pedersen; Poul H Jensen
Journal:  Protein Sci       Date:  2005-05-09       Impact factor: 6.725

3.  A fish-specific member of the TPPP protein family?

Authors:  Ferenc Orosz
Journal:  J Mol Evol       Date:  2012-10-07       Impact factor: 2.395

4.  Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease.

Authors:  B T Hyman; T E Elvhage; J Reiter
Journal:  Am J Pathol       Date:  1994-03       Impact factor: 4.307

5.  TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6.

Authors:  Natália Tokési; Attila Lehotzky; István Horváth; Bálint Szabó; Judit Oláh; Pierre Lau; Judit Ovádi
Journal:  J Biol Chem       Date:  2010-03-22       Impact factor: 5.157

6.  p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy.

Authors:  Yun Ju C Song; Ditte M S Lundvig; Yue Huang; Wei Ping Gai; Peter C Blumbergs; Peter Højrup; Daniel Otzen; Glenda M Halliday; Poul H Jensen
Journal:  Am J Pathol       Date:  2007-09-06       Impact factor: 4.307

7.  Drosophila Ringmaker regulates microtubule stabilization and axonal extension during embryonic development.

Authors:  Rosa E Mino; Stephen L Rogers; April L Risinger; Cristina Rohena; Swati Banerjee; Manzoor A Bhat
Journal:  J Cell Sci       Date:  2016-07-15       Impact factor: 5.285

8.  TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation.

Authors:  L Tirián; E Hlavanda; J Oláh; I Horváth; F Orosz; B Szabó; J Kovács; J Szabad; J Ovádi
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-17       Impact factor: 11.205

9.  A new protein superfamily: TPPP-like proteins.

Authors:  Ferenc Orosz
Journal:  PLoS One       Date:  2012-11-14       Impact factor: 3.240

10.  Molecular interaction of TPPP with PrP antagonized the CytoPrP-induced disruption of microtubule structures and cytotoxicity.

Authors:  Rui-Min Zhou; Yuan-Yuan Jing; Yan Guo; Chen Gao; Bao-Yun Zhang; Cao Chen; Qi Shi; Chan Tian; Zhao-Yun Wang; Han-Shi Gong; Jun Han; Bian-Li Xu; Xiao-Ping Dong
Journal:  PLoS One       Date:  2011-08-12       Impact factor: 3.240
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