Genetics of Wnt signaling during early mammalian development.

Proper cell-cell communication is necessary to orchestrate the cell fate determination, proliferation, movement, and differentiation that occurs during the development of a complex, multicellular organism. Members of the Wnt family of secreted signaling molecules regulate these processes in virtually every embryonic tissue and during the homeostatic maintenance of adult tissues. Mammalian genetic studies have been particularly useful in illustrating the specific roles that Wnt signaling pathways play in embryonic development, and in the etiology of diseases such as cancer. This chapter will largely focus on the functional roles that Wnts, signaling through the Wnt/-catenin pathway, play during early mammalian development.