Literature DB >> 19099249

Assaying beta-catenin/TCF transcription with beta-catenin/TCF transcription-based reporter constructs.

Travis L Biechele1, Randall T Moon.   

Abstract

Transcription-based reporters have been instrumental in characterizing the Wnt/beta-catenin signaling pathway and will be essential in the search for therapeutics aimed at combating diseases linked to aberrant signaling. In this chapter, we introduce a new improved Wnt/beta-catenin reporter system, beta-catenin-activated reporter (BAR), and its accompanying control reporter system, found unresponsive BAR (fuBAR). Its enhanced sensitivity, increased dynamic range, and lentiviral platform provide a reporter system that will keep pace with the needs of scientists in the field.

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Year:  2008        PMID： 19099249     DOI： 10.1007/978-1-59745-249-6_8

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  66 in total

1.  Calcium-mediated repression of β-catenin and its transcriptional signaling mediates neural crest cell death in an avian model of fetal alcohol syndrome.

Authors:  George R Flentke; Ana Garic; Ed Amberger; Marcos Hernandez; Susan M Smith
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2011-05-31

2.  Chemical-genetic screen identifies riluzole as an enhancer of Wnt/β-catenin signaling in melanoma.

Authors:  Travis L Biechele; Nathan D Camp; Daniel M Fass; Rima M Kulikauskas; Nick C Robin; Bryan D White; Corinne M Taraska; Erin C Moore; Jeanot Muster; Rakesh Karmacharya; Stephen J Haggarty; Andy J Chien; Randall T Moon
Journal:  Chem Biol       Date:  2010-11-24

Review 3.  Targeting Wnt pathways in disease.

Authors:  Zachary F Zimmerman; Randall T Moon; Andy J Chien
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-11-01       Impact factor: 10.005

4.  CaMKII represses transcriptionally active β-catenin to mediate acute ethanol neurodegeneration and can phosphorylate β-catenin.

Authors:  George R Flentke; Ana Garic; Marcos Hernandez; Susan M Smith
Journal:  J Neurochem       Date:  2013-10-24       Impact factor: 5.372

5.  Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.

Authors:  Zhihong Cheng; Travis Biechele; Zhiyi Wei; Seamus Morrone; Randall T Moon; Liguo Wang; Wenqing Xu
Journal:  Nat Struct Mol Biol       Date:  2011-10-09       Impact factor: 15.369

6.  Primary cilia regulate branching morphogenesis during mammary gland development.

Authors:  Kimberly M McDermott; Bob Y Liu; Thea D Tlsty; Gregory J Pazour
Journal:  Curr Biol       Date:  2010-04-08       Impact factor: 10.834

7.  The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice.

Authors:  Adriana Forero; Jennifer Tisoncik-Go; Tokiko Watanabe; Gongxun Zhong; Masato Hatta; Nicolas Tchitchek; Christian Selinger; Jean Chang; Kristi Barker; Juliet Morrison; Jason D Berndt; Randall T Moon; Laurence Josset; Yoshihiro Kawaoka; Michael G Katze
Journal:  J Virol       Date:  2015-12-09       Impact factor: 5.103

8.  Lentiviral vectors to probe and manipulate the Wnt signaling pathway.

Authors:  Christophe Fuerer; Roel Nusse
Journal:  PLoS One       Date:  2010-02-23       Impact factor: 3.240

9.  Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells.

Authors:  Sharon L Paige; Tomoaki Osugi; Olga K Afanasiev; Lil Pabon; Hans Reinecke; Charles E Murry
Journal:  PLoS One       Date:  2010-06-15       Impact factor: 3.240

10.  Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS).

Authors:  Olena Korvatska; Nicholas S Strand; Jason D Berndt; Tim Strovas; Dong-Hui Chen; James B Leverenz; Konstantin Kiianitsa; Ignacio F Mata; Emre Karakoc; J Lynne Greenup; Emily Bonkowski; Joseph Chuang; Randall T Moon; Evan E Eichler; Deborah A Nickerson; Cyrus P Zabetian; Brian C Kraemer; Thomas D Bird; Wendy H Raskind
Journal:  Hum Mol Genet       Date:  2013-04-16       Impact factor: 6.150
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