OBJECTIVES: The human leukocyte antigen (HLA) system includes genes involved in graft-vs-host rejection and in immune response. The discovery that HLAs are associated with several diseases led to appealing developments both in basic biomedical research and in clinical medicine, and offered the opportunity to improve the understanding of pathogenesis and classification of diseases, as well as to provide diagnostic and prognostic indicators. The aim of this article is to review the association between HLA alleles and autoimmune digestive disease and its current relationship with modern HLA nomenclature and clinical practice. METHODS: Articles dealing with the association between HLAs and autoimmune digestive disease (including celiac disease, inflammatory bowel disease, autoimmune hepatitis, sclerosing cholangitis and primary biliary cirrhosis) were searched for using Pubmed and SCOPUS databases from earliest records to January 2008. RESULTS: The review has provided two sections. In the first, we explain the basic principles of HLA structure, function, and nomenclature, as an introduction to the second section, which describes current associations between HLA alleles and digestive diseases. The clinical implications of each HLA association are critically discussed. Actually, a clinical role for HLA typing is suggested for only a few conditions, e.g., celiac disease. CONCLUSIONS: The knowledge of current HLA nomenclature and of its association with some digestive diseases such as celiac disease can be useful in clinical practice for diagnostic and prognostic purposes. This can avoid improper HLA typing as well as stressing the need for further studies on other possible clinical applications.
OBJECTIVES: The human leukocyte antigen (HLA) system includes genes involved in graft-vs-host rejection and in immune response. The discovery that HLAs are associated with several diseases led to appealing developments both in basic biomedical research and in clinical medicine, and offered the opportunity to improve the understanding of pathogenesis and classification of diseases, as well as to provide diagnostic and prognostic indicators. The aim of this article is to review the association between HLA alleles and autoimmune digestive disease and its current relationship with modern HLA nomenclature and clinical practice. METHODS: Articles dealing with the association between HLAs and autoimmune digestive disease (including celiac disease, inflammatory bowel disease, autoimmune hepatitis, sclerosing cholangitis and primary biliary cirrhosis) were searched for using Pubmed and SCOPUS databases from earliest records to January 2008. RESULTS: The review has provided two sections. In the first, we explain the basic principles of HLA structure, function, and nomenclature, as an introduction to the second section, which describes current associations between HLA alleles and digestive diseases. The clinical implications of each HLA association are critically discussed. Actually, a clinical role for HLA typing is suggested for only a few conditions, e.g., celiac disease. CONCLUSIONS: The knowledge of current HLA nomenclature and of its association with some digestive diseases such as celiac disease can be useful in clinical practice for diagnostic and prognostic purposes. This can avoid improper HLA typing as well as stressing the need for further studies on other possible clinical applications.
Authors: Michael Wittig; Jarl A Anmarkrud; Jan C Kässens; Simon Koch; Michael Forster; Eva Ellinghaus; Johannes R Hov; Sascha Sauer; Manfred Schimmler; Malte Ziemann; Siegfried Görg; Frank Jacob; Tom H Karlsen; Andre Franke Journal: Nucleic Acids Res Date: 2015-03-09 Impact factor: 16.971
Authors: J-P Achkar; L Klei; P I W de Bakker; G Bellone; N Rebert; R Scott; Y Lu; M Regueiro; A Brzezinski; M I Kamboh; C Fiocchi; B Devlin; M Trucco; S Ringquist; K Roeder; R H Duerr Journal: Genes Immun Date: 2011-12-15 Impact factor: 2.676
Authors: Marta Maia Bosca-Watts; Miguel Minguez; Dolores Planelles; Samuel Navarro; Alejandro Rodriguez; Jesus Santiago; Joan Tosca; Francisco Mora Journal: World J Gastroenterol Date: 2018-01-07 Impact factor: 5.742
Authors: Miren Vicuña Arregui; Jose Manuel Zozaya Urmeneta; Helena León Brito; Juan Pablo Martínez De Esteban; Carlos Prieto Martínez; Lluis Forga Llenas; Erkuden Aranburu Urtasun; Francisco Sala Pericas; Ramón Angós Musgo; Maria Rosario Mercado Gutierrez; Mercedes Palacios Sarrasqueta Journal: Ann Gastroenterol Date: 2016-12-16