Literature DB >> 19098522

Sarcoplasmic reticulum-mitochondrial symbiosis: bidirectional signaling in skeletal muscle.

Ann E Rossi1, Simona Boncompagni, Robert T Dirksen.   

Abstract

In mammalian skeletal muscle, an intimate association between the sarcoplasmic reticulum (SR) and mitochondria results in a symbiotic and privileged bidirectional communication between these organelles. Orthograde signaling reflects SR calcium (Ca) release stimulating mitochondrial adenosine triphosphate production via excitation-metabolism coupling. Retrograde signaling involves mitochondrial inhibition of local SR Ca release by controlling the redox environment of the Ca release unit.

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Year:  2009        PMID: 19098522      PMCID: PMC2740713          DOI: 10.1097/JES.0b013e3181911fa4

Source DB:  PubMed          Journal:  Exerc Sport Sci Rev        ISSN: 0091-6331            Impact factor:   6.230


  30 in total

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Review 9.  Improper Remodeling of Organelles Deputed to Ca2+ Handling and Aerobic ATP Production Underlies Muscle Dysfunction in Ageing.

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