| Literature DB >> 19098522 |
Ann E Rossi1, Simona Boncompagni, Robert T Dirksen.
Abstract
In mammalian skeletal muscle, an intimate association between the sarcoplasmic reticulum (SR) and mitochondria results in a symbiotic and privileged bidirectional communication between these organelles. Orthograde signaling reflects SR calcium (Ca) release stimulating mitochondrial adenosine triphosphate production via excitation-metabolism coupling. Retrograde signaling involves mitochondrial inhibition of local SR Ca release by controlling the redox environment of the Ca release unit.Entities:
Mesh:
Substances:
Year: 2009 PMID: 19098522 PMCID: PMC2740713 DOI: 10.1097/JES.0b013e3181911fa4
Source DB: PubMed Journal: Exerc Sport Sci Rev ISSN: 0091-6331 Impact factor: 6.230