Literature DB >> 19098450

Cancer gene silencing without DNA hypermethylation.

Qiang Yu1.   

Abstract

Both DNA hypermethylation and Polycomb-mediated histone methylation induce gene silencing in cancer, but largely in two separate paths. Hence, different pharmacologic approaches are required to reactivate genes silenced by distinct epigenetic mechanisms.

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Year:  2008        PMID： 19098450     DOI： 10.4161/epi.3.6.7202

Source DB:  PubMed          Journal:  Epigenetics        ISSN： 1559-2294            Impact factor:   4.528


  4 in total

1.  Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats.

Authors:  Athena Starlard-Davenport; Volodymyr P Tryndyak; Smitha R James; Adam R Karpf; John R Latendresse; Frederick A Beland; Igor P Pogribny
Journal:  Carcinogenesis       Date:  2009-12-14       Impact factor: 4.944

2.  Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors.

Authors:  Rutger J Wierda; Hedwich F Kuipers; Marja C J A van Eggermond; Anne Benard; Jan C van Leeuwen; Silvia Carluccio; Sacha B Geutskens; J Wouter Jukema; Victor E Marquez; Paul H A Quax; Peter J van den Elsen
Journal:  J Cell Mol Med       Date:  2012-08       Impact factor: 5.310

3.  UHRF1 Induces Methylation of the TXNIP Promoter and Down-Regulates Gene Expression in Cervical Cancer.

Authors:  Min Jun Kim; Han Ju Lee; Mee Young Choi; Sang Soo Kang; Yoon Sook Kim; Jeong Kyu Shin; Wan Sung Choi
Journal:  Mol Cells       Date:  2021-03-31       Impact factor: 5.034

Review 4.  Epigenetic inheritance and the missing heritability.

Authors:  Marco Trerotola; Valeria Relli; Pasquale Simeone; Saverio Alberti
Journal:  Hum Genomics       Date:  2015-07-28       Impact factor: 4.639
  4 in total

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