BACKGROUND: Early Childhood Caries (ECC) is one of the most common chronic childhood diseases. In spite of the global decrease in dental caries in the past decades, ECC has become a significant problem in many developing countries and also in a few industrialized nations. Saliva as a host factor can play an important role in the process of dental caries. OBJECTIVE: The aim of this study was to compare sIgA and IgG as saliva components between ECC and caries-free groups. METHODS: In this cross-sectional study, samples of unstimulated saliva of 90 children (45 in ECC group & 45 in caries-free group) were taken with Scully method. Then the concentration levels of sIgA and IgG were measured with Enzyme Linked Immunosorbent Assay and Single Radial Immunodiffusion methods. RESULTS: Mean concentration levels of salivary sIgA and IgG were significantly higher among children with ECC (p<0.05). There was also a weak inverse correlation between sIgA level and DMFT index in ECC group but it was not statistically significant (p=0.056). CONCLUSION: The high concentration of salivary immunoglobulin in children with ECC may be associated with an increased antigenic load, leading to high production of antibodies.
BACKGROUND: Early Childhood Caries (ECC) is one of the most common chronic childhood diseases. In spite of the global decrease in dental caries in the past decades, ECC has become a significant problem in many developing countries and also in a few industrialized nations. Saliva as a host factor can play an important role in the process of dental caries. OBJECTIVE: The aim of this study was to compare sIgA and IgG as saliva components between ECC and caries-free groups. METHODS: In this cross-sectional study, samples of unstimulated saliva of 90 children (45 in ECC group & 45 in caries-free group) were taken with Scully method. Then the concentration levels of sIgA and IgG were measured with Enzyme Linked Immunosorbent Assay and Single Radial Immunodiffusion methods. RESULTS: Mean concentration levels of salivary sIgA and IgG were significantly higher among children with ECC (p<0.05). There was also a weak inverse correlation between sIgA level and DMFT index in ECC group but it was not statistically significant (p=0.056). CONCLUSION: The high concentration of salivary immunoglobulin in children with ECC may be associated with an increased antigenic load, leading to high production of antibodies.
Authors: Gema Regina Guadarrama Santín; Angel Visoso Salgado; Norma Margarita Montiel Bastida; Isaías de la Rosa Gómez; Jonnathan Guadalupe Santillán Benítez; Hugo Mendieta Zerón Journal: Open Access Maced J Med Sci Date: 2017-03-03
Authors: Mohammed Ahsan Razi; Seema Qamar; Adya Singhal; Ankit Mahajan; Shandar Siddiqui; Ruchi Staffy Mohina Minz Journal: J Family Med Prim Care Date: 2020-03-26
Authors: Agnieszka Gornowicz; Grażyna Tokajuk; Anna Bielawska; Elżbieta Maciorkowska; Robert Jabłoński; Anna Wójcicka; Krzysztof Bielawski Journal: Med Sci Monit Date: 2014-06-29