BACKGROUND: A wide spectrum of human papillomavirus (HPV) types can infect the male genitalia. An HPV vaccine covering HPV6 and 11 is now available. Detailed data on the distribution of these two types in anogenital warts is needed to assess the potential benefits of the vaccine. STUDY DESIGN: Anogenital wart specimens collected from 130 Chinese men were examined for HPV-type distribution by a method that covers a broad spectrum of high- and low-risk HPVs, and able to reveal multiple types from a single specimen. RESULTS: Forty-four (33.8%) of the 130 specimens had a coinfection with multiple HPV types. In 63.1% of cases, only HPV6 and/or HPV11 were/was found. In 26.2% of cases, HPV6 and/or HPV11 were/was found together with one or more other HPV types. In 10.8% of specimens, only non-6/11 HPV types were found. HPV16 and/or 18 were/was found in 12 (9.2%) specimens, with majority (8/12, 66.7%) of which existed as coinfections with HPV6/11. Other HPV types found included HPV39, 51, 52, 55, 59, 61, 62, 68, 58, 72, 81, 83, 84 and CP6108. CONCLUSIONS: A substantial proportion of HPV6/11-positive male anogenital warts are coinfected with other HPV types. The efficacy of HPV6/11 vaccine for preventing these lesions needs to be defined before the benefits of vaccinating men can be precisely assessed.
BACKGROUND: A wide spectrum of human papillomavirus (HPV) types can infect the male genitalia. An HPV vaccine covering HPV6 and 11 is now available. Detailed data on the distribution of these two types in anogenital warts is needed to assess the potential benefits of the vaccine. STUDY DESIGN: Anogenital wart specimens collected from 130 Chinese men were examined for HPV-type distribution by a method that covers a broad spectrum of high- and low-risk HPVs, and able to reveal multiple types from a single specimen. RESULTS: Forty-four (33.8%) of the 130 specimens had a coinfection with multiple HPV types. In 63.1% of cases, only HPV6 and/or HPV11 were/was found. In 26.2% of cases, HPV6 and/or HPV11 were/was found together with one or more other HPV types. In 10.8% of specimens, only non-6/11 HPV types were found. HPV16 and/or 18 were/was found in 12 (9.2%) specimens, with majority (8/12, 66.7%) of which existed as coinfections with HPV6/11. Other HPV types found included HPV39, 51, 52, 55, 59, 61, 62, 68, 58, 72, 81, 83, 84 and CP6108. CONCLUSIONS: A substantial proportion of HPV6/11-positive male anogenital warts are coinfected with other HPV types. The efficacy of HPV6/11 vaccine for preventing these lesions needs to be defined before the benefits of vaccinating men can be precisely assessed.
Authors: Gabriella M Anic; Ji-Hyun Lee; Heather Stockwell; Dana E Rollison; Yougui Wu; Mary R Papenfuss; Luisa L Villa; Eduardo Lazcano-Ponce; Christine Gage; Roberto José C Silva; Maria L Baggio; Manuel Quiterio; Jorge Salmerón; Martha Abrahamsen; Anna R Giuliano Journal: J Infect Dis Date: 2011-10-19 Impact factor: 5.226
Authors: Staci L Sudenga; B Nelson Torres; William J Fulp; Roberto Silva; Luisa L Villa; Eduardo Lazcano-Ponce; Donna J Ingles; Mark Stoler; Jane L Messina; Martha Abrahamsen; Maria Luiza Baggio; Jorge Salmeron; Manuel Quiterio; Anna R Giuliano Journal: Int J Cancer Date: 2016-10-20 Impact factor: 7.396
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Authors: Beibei Lu; Raphael P Viscidi; Yougui Wu; Ji-Hyun Lee; Alan G Nyitray; Luisa L Villa; Eduardo Lazcano-Ponce; Roberto J Carvalho da Silva; Maria Luiza Baggio; Manuel Quiterio; Jorge Salmeron; Danelle C Smith; Martha E Abrahamsen; Mary R Papenfuss; Heather G Stockwell; Anna R Giuliano Journal: Cancer Res Date: 2011-11-28 Impact factor: 12.701
Authors: Shitaldas J Pamnani; Staci L Sudenga; Raphael Viscidi; Dana E Rollison; B Nelson Torres; Donna J Ingles; Martha Abrahamsen; Luisa L Villa; Eduardo Lazcano-Ponce; Jorge Salmeron; Manuel Quiterio; Yangxin Huang; Amy Borenstein; Anna R Giuliano Journal: Cancer Res Date: 2016-08-17 Impact factor: 12.701
Authors: Gabriella M Anic; Jane L Messina; Mark H Stoler; Dana E Rollison; Heather Stockwell; Luisa L Villa; Eduardo Lazcano-Ponce; Christine Gage; Roberto Jose C Silva; Maria L Baggio; Jorge Salmerón; Anna R Giuliano Journal: J Med Virol Date: 2013-09 Impact factor: 2.327