Literature DB >> 19097914

Synthesis and antibacterial property of quinolines with potent DNA gyrase activity.

Ekambaram Ramesh1, Rathna Durga R S Manian, Ragavachary Raghunathan, Shilpakala Sainath, Malathi Raghunathan.   

Abstract

Synthesis of a series of novel tetrahydroquinoline annulated heterocycles has been accomplished by intramolecular imino and bisimino Diels-Alder reaction. These compounds were evaluated for their antibacterial activity. All the synthetic compounds, exhibited good antibacterial activity against microorganisms of which one of them 7 was found to be as active as the antibiotic ciplofloxacin and is found to have MIC value of 2.5 mg/mL against Escherichia coli.

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Year:  2008        PMID： 19097914     DOI： 10.1016/j.bmc.2008.11.058

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  6 in total

Review 1.  In front of and behind the replication fork: bacterial type IIA topoisomerases.

Authors:  Claudia Sissi; Manlio Palumbo
Journal:  Cell Mol Life Sci       Date:  2010-02-18       Impact factor: 9.261

2.  In vitro activity of a new quinoline derivative, ER-2, against clinical isolates of Mycoplasma pneumoniae and Mycoplasma hominis.

Authors:  Shilpakala Sainath Rao; Raghavachari Raghunathan; Ramesh Ekambaram; Malathi Raghunathan
Journal:  Antimicrob Agents Chemother       Date:  2009-09-08       Impact factor: 5.191

3.  Facile Synthesis of Functionalized Phenoxy Quinolines: Antibacterial Activities against ESBL Producing Escherichia coli and MRSA, Docking Studies, and Structural Features Determination through Computational Approach.

Authors:  Mahwish Arshad; Nasir Rasool; Muhammad Usman Qamar; Syed Adnan Ali Shah; Zainul Amiruddin Zakaria
Journal:  Molecules       Date:  2022-06-10       Impact factor: 4.927

4.  Visible-Light-Driven Stereoselective Annulation of Alkyl Anilines and Dibenzoylethylenes via Electron Donor-Acceptor Complexes.

Authors:  August Runemark; Savannah C Zacharias; Henrik Sundén
Journal:  J Org Chem       Date:  2021-01-04       Impact factor: 4.354

Review 5.  The Cascade [1,5]-Hydride Shift/Intramolecular C(sp3)-H Activation: A Powerful Approach to the Construction of Spiro-Tetrahydroquinoline Skeleton.

Authors:  Hongmei Liu; Yunyun Quan; Long Xie; Xiang Li; Xin Xie
Journal:  Front Chem       Date:  2022-04-07       Impact factor: 5.545

6.  One-pot synthesis of indoles and quinolinones from ortho-tosylaminophenyl-substituted para-quinone methides.

Authors:  Junwei Wang; Xiang Pan; Quanjin Rong; Lei Zhao; Lin Zhao; Weichen Dai; Kun Zhao; Lihong Hu
Journal:  RSC Adv       Date:  2020-09-10       Impact factor: 4.036
  6 in total

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