Literature DB >> 19097909

Imaging the penumbra - strategies to detect tissue at risk after ischemic stroke.

M Ebinger1, D A De Silva, S Christensen, M W Parsons, R Markus, G A Donnan, S M Davis.   

Abstract

The aim of thrombolytic therapy after acute ischemic stroke is salvage of the ischemic penumbra. Several imaging techniques have been used to identify the penumbra in patients who may benefit from reperfusion beyond the currently narrow 3-hour time-window for thrombolysis. We discuss the advantages and disadvantages of positron emission tomography (PET), single photon emission computed tomography (SPECT), MRI and CT scans. We comment on concepts of clinical-imaging mismatch models and we explore the implications for clinical trials.

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Year:  2008        PMID： 19097909     DOI： 10.1016/j.jocn.2008.04.002

Source DB:  PubMed          Journal:  J Clin Neurosci        ISSN： 0967-5868            Impact factor:   1.961


  16 in total

1.  Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke.

Authors:  Ludmila Belayev; Sung-Ha Hong; Hemant Menghani; Shawn J Marcell; Andre Obenaus; Raul S Freitas; Larissa Khoutorova; Veronica Balaszczuk; Bokkyoo Jun; Reinaldo B Oriá; Nicolas G Bazan
Journal:  Mol Neurobiol       Date:  2018-06-01       Impact factor: 5.590

Review 2.  Intranasal Insulin and Insulin-Like Growth Factor 1 as Neuroprotectants in Acute Ischemic Stroke.

Authors:  Vasileios-Arsenios Lioutas; Freddy Alfaro-Martinez; Francisco Bedoya; Chen-Chih Chung; Daniela A Pimentel; Vera Novak
Journal:  Transl Stroke Res       Date:  2015-06-05       Impact factor: 6.829

3.  Mean transit time on Aquilion ONE and its utilization in patients undergoing acute stroke intervention.

Authors:  Haitham Dababneh; Asif Bashir; Waldo R Guerrero; Kelvin Wilson; Mohammed Hussain; Sara Misthal; Walter Morgan; Keith Peters; Jawad F Kirmani; J Mocco
Journal:  J Vasc Interv Neurol       Date:  2014-12

Review 4.  The science of stroke: mechanisms in search of treatments.

Authors:  Michael A Moskowitz; Eng H Lo; Costantino Iadecola
Journal:  Neuron       Date:  2010-07-29       Impact factor: 17.173

5.  Long-term survival and serial assessment of stroke damage and recovery - practical and methodological considerations.

Authors:  Michel Modo
Journal:  J Exp Stroke Transl Med       Date:  2009-01

6.  Targeting ischemic penumbra Part II: selective drug delivery using liposome technologies.

Authors:  Shimin Liu; Steven R Levine; H Richard Winn
Journal:  J Exp Stroke Transl Med       Date:  2011

7.  Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke.

Authors:  Nicolas G Bazan; Tiffany N Eady; Larissa Khoutorova; Kristal D Atkins; Song Hong; Yan Lu; Changde Zhang; Bokkyoo Jun; Andre Obenaus; Gabrielle Fredman; Min Zhu; Jeremy W Winkler; Nicos A Petasis; Charles N Serhan; Ludmila Belayev
Journal:  Exp Neurol       Date:  2012-04-19       Impact factor: 5.330

8.  Targeting ischemic penumbra: part I - from pathophysiology to therapeutic strategy.

Authors:  Shimin Liu; Steven R Levine; H Richard Winn
Journal:  J Exp Stroke Transl Med       Date:  2010-03-15

9.  Improving acute stroke management with computed tomography perfusion: a review of imaging basics and applications.

Authors:  C D d'Esterre; Enrico Fainardi; R I Aviv; T Y Lee
Journal:  Transl Stroke Res       Date:  2012-05-24       Impact factor: 6.829

10.  Occurrence and predictors of futile recanalization following endovascular treatment among patients with acute ischemic stroke: a multicenter study.

Authors:  H M Hussein; A L Georgiadis; G Vazquez; J T Miley; M Z Memon; Y M Mohammad; G A Christoforidis; N Tariq; A I Qureshi
Journal:  AJNR Am J Neuroradiol       Date:  2010-01-14       Impact factor: 3.825
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