| Literature DB >> 19097889 |
Shangjie Xu1, Ying Luo, Ralph Graeser, André Warnecke, Felix Kratz, Peter Hauff, Kai Licha, Rainer Haag.
Abstract
In this paper new dendritic core-shell architectures with pH-labile linkers based on hyperbranched polyglycerol cores and biocompatible poly(ethylene glycol) shells were synthesized which encapsulate the anticancer agent doxorubicin and a dye for near-infrared imaging, an indotricarbocyanine. Acid-sensitive properties of the new nanocarriers and in vitro cytotoxicity of the doxorubicin-nanocarrier are presented as well as preliminary data regarding their toxicity and tumor targeting potential in nude mice.Entities:
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Year: 2008 PMID： 19097889 DOI： 10.1016/j.bmcl.2008.01.043
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823