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Literature DB >> 19097888

Synthesis and CB1 cannabinoid receptor affinity of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles.

Hong Shu¹, Sari Izenwasser, Dean Wade, Edwin D Stevens, Mark L Trudell.

Abstract

A series of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles were synthesized regioselectively using click chemistry and evaluated at CB1 cannabinoid receptors. The n-propyl ester 11 (K(i)=4.6 nM) and phenyl ester 14 (K(i)=11 nM) exhibited the most potent affinity of the series.

Entities: Chemical Disease Gene Species

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Year: 2008 PMID： 19097888 PMCID： PMC2631625 DOI： 10.1016/j.bmcl.2008.11.110

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

31 in total

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4 in total