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Literature DB >> 19097780

Identification and functional analysis of brassicicene C biosynthetic gene cluster in Alternaria brassicicola.

Atsushi Minami¹, Naoto Tajima, Yusuke Higuchi, Tomonobu Toyomasu, Takeshi Sassa, Nobuo Kato, Tohru Dairi.

Abstract

The biosynthetic gene cluster of brassicicene C was identified in Alternaria brassicicola strain ATCC 96836 from genome database search. In vivo and in vitro study clearly revealed the function of Orf8 and Orf6 as a fusicoccadiene synthase and methyltransferase, respectively. The understanding toward the biosynthetic pathway promises construction of this type of diterpene compounds with genetic engineering.

Entities: Chemical Species

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Year: 2008 PMID： 19097780 DOI： 10.1016/j.bmcl.2008.11.108

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

11 in total

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2. Molecular breeding of a fungus producing a precursor diterpene suitable for semi-synthesis by dissection of the biosynthetic machinery.

Authors: Motoyoshi Noike; Yusuke Ono; Yuji Araki; Ryo Tanio; Yusuke Higuchi; Hajime Nitta; Yoshimitsu Hamano; Tomonobu Toyomasu; Takeshi Sassa; Nobuo Kato; Tohru Dairi
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Review 3. Diterpene synthases and their responsible cyclic natural products.

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Journal: Nat Prod Bioprospect Date: 2014-04-18

4. Heterologous fermentation of a diterpene from Alternaria brassisicola.

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Journal: Mycology Date: 2014-05-28

5. Sesterterpene ophiobolin biosynthesis involving multiple gene clusters in Aspergillus ustus.

Authors: Hangzhen Chai; Ru Yin; Yongfeng Liu; Huiying Meng; Xianqiang Zhou; Guolin Zhou; Xupeng Bi; Xue Yang; Tonghan Zhu; Weiming Zhu; Zixin Deng; Kui Hong
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6. Transcriptome sequencing of Mycosphaerella fijiensis during association with Musa acuminata reveals candidate pathogenicity genes.

Authors: Roslyn D Noar; Margaret E Daub
Journal: BMC Genomics Date: 2016-08-30 Impact factor: 3.969

Identification and functional analysis of brassicicene C biosynthetic gene cluster in Alternaria brassicicola.

Review 1. Traversing the fungal terpenome.

2. Molecular breeding of a fungus producing a precursor diterpene suitable for semi-synthesis by dissection of the biosynthetic machinery.

Review 3. Diterpene synthases and their responsible cyclic natural products.

4. Heterologous fermentation of a diterpene from Alternaria brassisicola.

5. Sesterterpene ophiobolin biosynthesis involving multiple gene clusters in Aspergillus ustus.

6. Transcriptome sequencing of Mycosphaerella fijiensis during association with Musa acuminata reveals candidate pathogenicity genes.

7. Two Diterpene Synthases from Chryseobacterium: Chryseodiene Synthase and Wanjudiene Synthase.

8. Glucose limited feed strategy leads to increased production of fusicocca-2,10(14)-diene by Saccharomyces cerevisiae.

9. Characterization of a new fusicoccane-type diterpene synthase and an associated P450 enzyme.

Review 10. Diterpenes Specially Produced by Fungi: Structures, Biological Activities, and Biosynthesis (2010-2020).