AIMS: To examine the effects of a 24-week lifestyle intervention prescribed by family doctors on carotid artery stiffness in metabolic syndrome (MS) subjects with pre-hypertension and/or pre-diabetes. METHODS: Sixty-three middle-aged and older subjects with pre-hypertension and/or pre-diabetes were divided into subjects without MS (MS-) and with MS (MS+). MS components and carotid artery stiffness by ultrasound were determined at baseline, at 8 weeks, and following the 24 weeks of lifestyle intervention. Family doctors prescribed an individually customized lifestyle prescription for aerobic exercise and Mediterranean-style diet. RESULTS: Carotid artery distensibility significantly increased in MS+ following the 24 weeks of intervention compared with baseline (0.191+/-0.012 vs. 0.143+/-0.011, 1/mmHg x 10(-2), p<0.05). Similarly, beta stiffness index decreased in MS+ following the 24 weeks of intervention (9.8+/-1.1 vs. 12.5+/-1.1 AU, p<0.05). Following the intervention, waist circumference, BP and fasting glucose levels reduced in MS+ (all p<0.05), and 13 MS+ subjects were free from MS. CONCLUSIONS: The results show the reduction of carotid artery stiffness and the improvement of some MS components in MS subjects, suggesting a favorable effect of our lifestyle modification strategy on central artery stiffness as well as MS components in MS subjects.
AIMS: To examine the effects of a 24-week lifestyle intervention prescribed by family doctors on carotid artery stiffness in metabolic syndrome (MS) subjects with pre-hypertension and/or pre-diabetes. METHODS: Sixty-three middle-aged and older subjects with pre-hypertension and/or pre-diabetes were divided into subjects without MS (MS-) and with MS (MS+). MS components and carotid artery stiffness by ultrasound were determined at baseline, at 8 weeks, and following the 24 weeks of lifestyle intervention. Family doctors prescribed an individually customized lifestyle prescription for aerobic exercise and Mediterranean-style diet. RESULTS: Carotid artery distensibility significantly increased in MS+ following the 24 weeks of intervention compared with baseline (0.191+/-0.012 vs. 0.143+/-0.011, 1/mmHg x 10(-2), p<0.05). Similarly, beta stiffness index decreased in MS+ following the 24 weeks of intervention (9.8+/-1.1 vs. 12.5+/-1.1 AU, p<0.05). Following the intervention, waist circumference, BP and fasting glucose levels reduced in MS+ (all p<0.05), and 13 MS+ subjects were free from MS. CONCLUSIONS: The results show the reduction of carotid artery stiffness and the improvement of some MS components in MS subjects, suggesting a favorable effect of our lifestyle modification strategy on central artery stiffness as well as MS components in MS subjects.
Authors: David de Gonzalo-Calvo; Benjamín Fernández-García; Beatriz de Luxán-Delgado; Susana Rodríguez-González; Marina García-Macia; Francisco Manuel Suárez; Juan José Solano; María Josefa Rodríguez-Colunga; Ana Coto-Montes Journal: Age (Dordr) Date: 2012-01-04
Authors: Eric D Vidoni; Anna Mattlage; Jonathan Mahnken; Jeffrey M Burns; Joe McDonough; Sandra A Billinger Journal: J Aging Phys Act Date: 2012-12-10 Impact factor: 1.961
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Authors: Abd Al Rahman Al-Shudiefat; Anita K Sharma; Ashim K Bagchi; Sanjiv Dhingra; Pawan K Singal Journal: Mol Cell Biochem Date: 2012-09-08 Impact factor: 3.396