| Literature DB >> 19096999 |
Su-Ui Lee, Ki Shuk Shim, Shi Yong Ryu, Yong Ki Min, Seong Hwan Kim.
Abstract
This study evaluated the stimulatory effects of machilin A and structurally related lignans isolated from Myristica fragrans on osteoblast differentiation. In two IN VITRO osteoblast differentiation models, machilin A stimulated osteoblast differentiation via activation of p38 MAP kinase. Lignans isolated from Myristica fragrans also stimulated osteoblast differentiation in MC3T3-E1 cells; the lignans included macelignan, machilin F, nectandrin B, safrole, licarin A, licarin B, myristargenol, and meso-dihydroguaiaretic acid. These data suggest that lignans isolated from Myristica fragrans have anabolic activity in bone metabolism.Entities:
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Year: 2008 PMID： 19096999 DOI： 10.1055/s-0028-1112197
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352