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Literature DB >> 19096810

[Multiple skin cancers in a patient treated with hydroxyurea].

A Wiechert¹, G Reinhard, T Tüting, M Uerlich, T Bieber, J Wenzel.

Abstract

A 62-year-old patient treated for 9 years with hydroxyurea for chronic myeloproliferative disease developed multiple cutaneous neoplasms. Hydroxyurea minimizes DNA synthesis via inhibition of the enzyme ribonucleotide reductase and is used to treat hematological malignancies. The most important and severe side-effect is a dose-dependent myelodepression. An association with multiple skin tumors has been reported. The presented case emphasizes this potential risk of hydroxyurea therapy. Continuous dermatologic monitoring of patients treated with hydroxyurea is recommended.

Entities: Chemical Disease Species

Mesh：

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Year: 2009 PMID： 19096810 DOI： 10.1007/s00105-008-1673-1

Source DB: PubMed Journal: Hautarzt ISSN： 0017-8470 Impact factor: 0.751

12 in total

2. Acquired melanonychia in chilean patients with essential thrombocythemia treated with hydroxyurea: a report of 7 clinical cases and review of the literature.

Authors: Nigel P Murray; Pablo Tapia; Jose Porcell; Maximiliano Echavarria; Hernán Suazo
Journal: ISRN Dermatol Date: 2013-02-07

2 in total

[Multiple skin cancers in a patient treated with hydroxyurea].

1. The cutaneous side-effects of hydroxyurea.

2. Association of cutaneous side-effects of hydroxyurea and neuroendocrine carcinoma.

3. Skin cancer in immunosuppressed patients.

4. Inhibition of DNA repair in ultraviolet-irradiated human cells by hydroxyurea.

5. Cutaneous manifestations of long-term hydroxyurea therapy.

Review 6. Oral squamous cell carcinoma during long-term treatment with hydroxyurea.

7. Metastatic squamous cell carcinoma of the skin in chronic myeloid leukaemia: complication of hydroxyurea therapy.

8. Clonal integration of a polyomavirus in human Merkel cell carcinoma.

Review 9. Chronic myeloproliferative disorders.

10. Multiple squamous cell carcinomas of the skin during long-term treatment with hydroxyurea.

1. Primary cutaneous undifferentiated round cell tumor with concurrent polymyositis in a dog.

2. Acquired melanonychia in chilean patients with essential thrombocythemia treated with hydroxyurea: a report of 7 clinical cases and review of the literature.