Literature DB >> 19096802

Generation of hepatocytes from human embryonic stem cells.

Niloufar Safinia1, Stephen L Minger.   

Abstract

Use of human hepatocytes for therapeutic and drug discovery applications is hampered by limited tissue source and the inability of hepatocytes to proliferate and maintain function long-term in vitro. Human embryonic stem (hES) cells are immortal and pluripotent and may provide a cell source for functional human hepatocytes (1) Here we have outlined some of the protocols currently in use for the generation of hepatocytes from hES cells.

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Year:  2009        PMID: 19096802     DOI: 10.1007/978-1-59745-201-4_14

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN: 1064-3745


  3 in total

1.  Fate mapping of human embryonic stem cells by teratoma formation.

Authors:  Carissa Ritner; Harold S Bernstein
Journal:  J Vis Exp       Date:  2010-08-01       Impact factor: 1.355

Review 2.  Cell-based therapies of liver diseases: age-related challenges.

Authors:  Konstantin N Yarygin; Alexei Y Lupatov; Irina V Kholodenko
Journal:  Clin Interv Aging       Date:  2015-12-01       Impact factor: 4.458

3.  Modeling endodermal organ development and diseases using human pluripotent stem cell-derived organoids.

Authors:  Fong Cheng Pan; Todd Evans; Shuibing Chen
Journal:  J Mol Cell Biol       Date:  2020-08-01       Impact factor: 6.216

  3 in total

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