Literature DB >> 1909594

CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire.

J C Zúñiga-Pflücker1, L A Jones, L T Chin, A M Kruisbeek.   

Abstract

The selection of T cell receptor specificities must logically not only involve the alpha beta-TCR but, also the CD4 and CD8 molecules, as antigen recognition by the alpha beta-TCR on mature T cells is facilitated by the CD4 and CD8 co-receptors. In this review, the studies that provided key advances in our understanding of the possible role of CD4 and CD8 in T cell development will be discussed.

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Year:  1991        PMID： 1909594

Source DB:  PubMed          Journal:  Semin Immunol        ISSN： 1044-5323            Impact factor:   11.130


  8 in total

1.  Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.

Authors:  S S Rhee; J W Marsh
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

2.  Lipopolysaccharide (LPS) down-regulates CD4 expression in primary human macrophages through induction of endogenous tumour necrosis factor (TNF) and IL-1 beta.

Authors:  G Herbein; A G Doyle; L J Montaner; S Gordon
Journal:  Clin Exp Immunol       Date:  1995-11       Impact factor: 4.330

3.  T cell receptor signaling that regulates the development of intrathymic natural regulatory T cells.

Authors:  Ki-Duk Song; Sujin Hwang; Cheol-Heui Yun
Journal:  Immune Netw       Date:  2011-12-31       Impact factor: 6.303

4.  p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.

Authors:  D Jiang; M J Lenardo; J C Zúñiga-Pflücker
Journal:  J Exp Med       Date:  1996-04-01       Impact factor: 14.307

5.  Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage.

Authors:  C P Liu; J W Kappler; P Marrack
Journal:  J Exp Med       Date:  1996-11-01       Impact factor: 14.307

6.  In vivo persistence of expanded clones specific for bacterial antigens within the human T cell receptor alpha/beta CD4-8- subset.

Authors:  P Dellabona; G Casorati; B Friedli; L Angman; F Sallusto; A Tunnacliffe; E Roosneek; A Lanzavecchia
Journal:  J Exp Med       Date:  1993-06-01       Impact factor: 14.307

7.  Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sorting.

Authors:  A Pelchen-Matthews; I J Parsons; M Marsh
Journal:  J Exp Med       Date:  1993-10-01       Impact factor: 14.307

8.  Distinctive selection mechanisms govern the T cell receptor repertoire of peripheral CD4-CD8- alpha/beta T cells.

Authors:  L Huang; I N Crispe
Journal:  J Exp Med       Date:  1992-09-01       Impact factor: 14.307
  8 in total

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