BACKGROUND: Although common genetic variants of the CRP gene (C-reactive protein, pentraxin related) have been associated with plasma concentrations of high-sensitivity CRP (hsCRP) in several cohorts of European Americans, relatively few studies have comprehensively assessed this association in well-characterized multiethnic populations. METHODS: In a case-control study of diabetes nested in the Women's Health Initiative Observational Cohort, we comprehensively evaluated the association of genetic variation in CRP with plasma hsCRP concentrations. Thirteen haplotype-tagging single-nucleotide polymorphisms (tSNPs) were identified and subsequently genotyped in 3782 postmenopausal women. RESULTS: The allele frequencies for these tSNPs and the haplotype blocks defined by these tSNPs varied significantly by ethnic group (P < 0.0001). Consistent with prior studies of whites, rs3093068, rs1130864, and rs1417938 were significantly associated with higher hsCRP concentrations (geometric-mean increase per minor-allele change, 1.20-1.25 mg/L), and rs1205 and rs1800947 were significantly associated with lower hsCRP values (decrease of 1.28-1.48 mg/L). The associations with rs3093068 and rs1205 appeared to be stronger in Asians/Pacific Islanders than in whites (geometric-mean increase, 1.65 mg/L vs 1.25 mg/L, respectively). Minor alleles at rs3093075 and rs3093059 were associated with substantially increased hsCRP concentrations, whereas rs1800947 was associated with lower hsCRP values. All haplotype-based association results tended to be consistent with the associations seen with single CRP SNPs. CONCLUSIONS: Our large multiethnic case-control study of postmenopausal women provides evidence that common genetic variants in the CRP gene are substantially associated with plasma hsCRP concentrations in this case-control subcohort. The data also suggest ethnic variations in these associations.
BACKGROUND: Although common genetic variants of the CRP gene (C-reactive protein, pentraxin related) have been associated with plasma concentrations of high-sensitivity CRP (hsCRP) in several cohorts of European Americans, relatively few studies have comprehensively assessed this association in well-characterized multiethnic populations. METHODS: In a case-control study of diabetes nested in the Women's Health Initiative Observational Cohort, we comprehensively evaluated the association of genetic variation in CRP with plasma hsCRP concentrations. Thirteen haplotype-tagging single-nucleotide polymorphisms (tSNPs) were identified and subsequently genotyped in 3782 postmenopausal women. RESULTS: The allele frequencies for these tSNPs and the haplotype blocks defined by these tSNPs varied significantly by ethnic group (P < 0.0001). Consistent with prior studies of whites, rs3093068, rs1130864, and rs1417938 were significantly associated with higher hsCRP concentrations (geometric-mean increase per minor-allele change, 1.20-1.25 mg/L), and rs1205 and rs1800947 were significantly associated with lower hsCRP values (decrease of 1.28-1.48 mg/L). The associations with rs3093068 and rs1205 appeared to be stronger in Asians/Pacific Islanders than in whites (geometric-mean increase, 1.65 mg/L vs 1.25 mg/L, respectively). Minor alleles at rs3093075 and rs3093059 were associated with substantially increased hsCRP concentrations, whereas rs1800947 was associated with lower hsCRP values. All haplotype-based association results tended to be consistent with the associations seen with single CRP SNPs. CONCLUSIONS: Our large multiethnic case-control study of postmenopausal women provides evidence that common genetic variants in the CRP gene are substantially associated with plasma hsCRP concentrations in this case-control subcohort. The data also suggest ethnic variations in these associations.
Authors: Leslie A Lange; Kathryn Burdon; Carl D Langefeld; Yongmei Liu; Stephanie R Beck; Stephen S Rich; Barry I Freedman; K Bridget Brosnihan; David M Herrington; Lynne E Wagenknecht; Donald W Bowden Journal: Ann Hum Genet Date: 2006-11 Impact factor: 1.670
Authors: Abbas Dehghan; Isabella Kardys; Moniek P M de Maat; Andre G Uitterlinden; Eric J G Sijbrands; Aart H Bootsma; Theo Stijnen; Albert Hofman; Miranda T Schram; Jacqueline C M Witteman Journal: Diabetes Date: 2007-03 Impact factor: 9.461
Authors: Robert Y L Zee; Soren Germer; Abraham Thomas; Annaswammy Raji; Brian Rhees; Paul M Ridker; Klaus Lindpaintner; Gordon H Williams; David M Nathan; Mitchell Martin Journal: Atherosclerosis Date: 2007-09-27 Impact factor: 5.162
Authors: Simin Liu; Lesley Tinker; Yiqing Song; Nader Rifai; Denise E Bonds; Nancy R Cook; Gerardo Heiss; Barbara V Howard; Gokhan S Hotamisligil; Frank B Hu; Lewis H Kuller; JoAnn E Manson Journal: Arch Intern Med Date: 2007 Aug 13-27
Authors: Dana C Crawford; Qian Yi; Joshua D Smith; Cynthia Shephard; Michelle Wong; Laura Witrak; Robert J Livingston; Mark J Rieder; Deborah A Nickerson Journal: Hum Genet Date: 2006-03-21 Impact factor: 4.132
Authors: David Serre; Alexandre Montpetit; Guillaume Paré; James C Engert; Salim Yusuf; Bernard Keavney; Thomas J Hudson; Sonia Anand Journal: PLoS One Date: 2008-01-02 Impact factor: 3.240
Authors: Vasiliki Michopoulos; Alex O Rothbaum; Tanja Jovanovic; Lynn M Almli; Bekh Bradley; Barbara O Rothbaum; Charles F Gillespie; Kerry J Ressler Journal: Am J Psychiatry Date: 2014-12-12 Impact factor: 18.112
Authors: Ayo P Doumatey; Guanjie Chen; Fasil Tekola Ayele; Jie Zhou; Michael Erdos; Daniel Shriner; Hanxia Huang; Jokotade Adeleye; Williams Balogun; Olufemi Fasanmade; Thomas Johnson; Johnnie Oli; Godfrey Okafor; Albert Amoah; Benjamin A Eghan; Kofi Agyenim-Boateng; Joseph Acheampong; Clement Adebamowo; Norman P Gerry; Michael F Christman; Adebowale Adeyemo; Charles N Rotimi Journal: Hum Mol Genet Date: 2012-04-05 Impact factor: 6.150
Authors: Martha L Slattery; Karen Curtin; Elizabeth M Poole; David J Duggan; Wade S Samowitz; Ulrike Peters; Bette J Caan; John D Potter; Cornelia M Ulrich Journal: Int J Cancer Date: 2010-11-28 Impact factor: 7.396
Authors: Anna C Rivara; Margaret Corley; Courtney C Choy; Rachel L Duckham; Alysa Pomer; Muagututia Sefuiva Reupena; Satupaitea Viali; Take Naseri; Erin E Kershaw; Scott E Crouter; Stephen T McGarvey; Richard G Bribiescas; Claudia Valeggia; Nicola L Hawley Journal: Am J Hum Biol Date: 2021-07-14 Impact factor: 1.937