Literature DB >> 1909540

Transdermal nitrate therapy: bioavailability during exercise increases transiently after the daily change of patch.

K Gjesdal1, T O Klemsdal, E O Rykke, J E Bredesen.   

Abstract

Ten volunteers carried a 10 mg 24 h -1 transdermal glyceryl trinitrate (GTN) patch for 24 h before moderate exercise. Plasma GTN-concentration increased significantly (P less than 0.05) by 19% to peak value at 15 min. Two hours after patch renewal repeat exercise increased GTN concentration by 56% (P less than 0.001). The two nitrate-concentration curves differed significantly (P less than 0.0001). Thus, change of patch augmented nitrate availability during exercise.

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Year:  1991        PMID： 1909540      PMCID： PMC1368478          DOI： 10.1111/j.1365-2125.1991.tb05582.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  7 in total

1.  Increased uptake of transdermal glyceryl trinitrate during physical exercise and during high ambient temperature.

Authors:  T F Barkve; K Langseth-Manrique; J E Bredesen; K Gjesdal
Journal:  Am Heart J       Date:  1986-09       Impact factor: 4.749

2.  Effect of posture on glyceryl trinitrate plasma concentrations following transdermal application.

Authors:  R Heidemann; C Beckenbauer; B G Woodcock
Journal:  Br J Clin Pharmacol       Date:  1987-02       Impact factor: 4.335

3.  The effects of moderate sustained exercise on the pharmacokinetics of nitroglycerine.

Authors:  S Weber; D de Lauture; E Rey; T Darragon; J P Severins; A Ditisheim; G Olive; M Degeorges
Journal:  Br J Clin Pharmacol       Date:  1987-01       Impact factor: 4.335

4.  [Interval therapy in effective treatment of angina pectoris using nitroglycerin patch systems. A controlled study with determination of nitroglycerin plasma levels].

Authors:  G Reiniger; G Menke; A Boertz; F Kraus; W Rudolph
Journal:  Herz       Date:  1987-02       Impact factor: 1.443

5.  Influence of posture on plasma nitroglycerin.

Authors:  S H Curry; H R Kwon
Journal:  Br J Clin Pharmacol       Date:  1985-03       Impact factor: 4.335

6.  Rapid, isothermal gas-liquid chromatographic determination of nitroglycerine in plasma using an electron-capture detector. II.

Authors:  K Langseth-Manrique; J E Bredesen; T Greibrokk
Journal:  J Chromatogr       Date:  1985-12-11

7.  New transdermal and transmucosal nitroglycerin delivery systems in patients with ischaemic heart disease.

Authors:  V I Metelitsa; V K Piotrovskii; O S Ryabokon; S V Blagodatskikh
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953
  7 in total
  10 in total

1.  Heating and cooling of the nitroglycerin patch application area modify the plasma level of nitroglycerin.

Authors:  T O Klemsdal; K Gjesdal; J E Bredesen
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

2.  The effect of transdermal nitroglycerin on exercise tolerance in relation to patch application time--a meta-analysis.

Authors:  T O Klemsdal; K Gjesdal
Journal:  Cardiovasc Drugs Ther       Date:  1992-12       Impact factor: 3.727

3.  Novel pharmacokinetic modelling of transdermal nitroglycerin.

Authors:  B Auclair; G Sirois; A H Ngoc; M P Ducharme
Journal:  Pharm Res       Date:  1998-04       Impact factor: 4.200

4.  Transdermal patch drug delivery interactions with exercise.

Authors:  Thomas L Lenz; Nicole Gillespie
Journal:  Sports Med       Date:  2011-03-01       Impact factor: 11.136

5.  Physical exercise increases plasma concentrations of nicotine during treatment with a nicotine patch.

Authors:  T O Klemsdal; K Gjesdal; K Zahlsen
Journal:  Br J Clin Pharmacol       Date:  1995-06       Impact factor: 4.335

6.  Characterization of Temperature Profiles in Skin and Transdermal Delivery System When Exposed to Temperature Gradients In Vivo and In Vitro.

Authors:  Qian Zhang; Michael Murawsky; Terri LaCount; Jinsong Hao; Gerald B Kasting; Bryan Newman; Priyanka Ghosh; Sam G Raney; S Kevin Li
Journal:  Pharm Res       Date:  2017-05-10       Impact factor: 4.200

Review 7.  Clinical pharmacokinetics and pharmacodynamics of glyceryl trinitrate and its metabolites.

Authors:  Satoru Hashimoto; Atsuko Kobayashi
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447

Review 8.  Clinical pharmacokinetics of nitrates.

Authors:  M G Bogaert
Journal:  Cardiovasc Drugs Ther       Date:  1994-10       Impact factor: 3.727

Review 9.  Heat effects on drug delivery across human skin.

Authors:  Jinsong Hao; Priyanka Ghosh; S Kevin Li; Bryan Newman; Gerald B Kasting; Sam G Raney
Journal:  Expert Opin Drug Deliv       Date:  2016-01-25       Impact factor: 6.648

Review 10.  Ointments and transdermal nitroglycerin patches for stable angina pectoris.

Authors:  U Thadani; R J Lipicky
Journal:  Cardiovasc Drugs Ther       Date:  1994-08       Impact factor: 3.727
  10 in total

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