PURPOSE: To report the reproducibility of macular pigment optical density (MPOD) values assessed with heterochromatic flicker photometry (HFP) in healthy individuals. METHODS: Twenty-four volunteers from our department underwent MPOD testing of both eyes by flicker photometry on three separate occasions. To test reproducibility of MPOD, the coefficient of variance was calculated separately for right and left eyes. In addition, we investigated MPOD averages of right and left eyes and interocular correlations (Pearson's r) at every visit. RESULTS: The mean MPODs at the first visit were 0.61 +/- 0.24 and 0.72 +/- 0.27 in right and left eyes, respectively. Mean values of 0.58 +/- 0.29 and 0.60 +/- 0.21 (second visit) and 0.62 +/- 0.27 and 0.63 +/- 0.24 (third visit) were assessed for right and left eyes, respectively. Differences of the mean values between eyes were not significant. Correlations were weak at visits one and two (r = 0.49, p < 0.014 and r = 0.43, p < 0.038, respectively) and moderate at visit three (r = 0.58, p < 0.003). The coefficients of variance were 36.1% and 23% for right and left eyes, respectively. CONCLUSION: Our mean MPODs are higher and the interocular correlations weaker compared to the literature. The coefficient of variance in both eyes is high and does not imply good reproducibility of obtained MPOD values.
PURPOSE: To report the reproducibility of macular pigment optical density (MPOD) values assessed with heterochromatic flicker photometry (HFP) in healthy individuals. METHODS: Twenty-four volunteers from our department underwent MPOD testing of both eyes by flicker photometry on three separate occasions. To test reproducibility of MPOD, the coefficient of variance was calculated separately for right and left eyes. In addition, we investigated MPOD averages of right and left eyes and interocular correlations (Pearson's r) at every visit. RESULTS: The mean MPODs at the first visit were 0.61 +/- 0.24 and 0.72 +/- 0.27 in right and left eyes, respectively. Mean values of 0.58 +/- 0.29 and 0.60 +/- 0.21 (second visit) and 0.62 +/- 0.27 and 0.63 +/- 0.24 (third visit) were assessed for right and left eyes, respectively. Differences of the mean values between eyes were not significant. Correlations were weak at visits one and two (r = 0.49, p < 0.014 and r = 0.43, p < 0.038, respectively) and moderate at visit three (r = 0.58, p < 0.003). The coefficients of variance were 36.1% and 23% for right and left eyes, respectively. CONCLUSION: Our mean MPODs are higher and the interocular correlations weaker compared to the literature. The coefficient of variance in both eyes is high and does not imply good reproducibility of obtained MPOD values.
Authors: R de Kinkelder; R L P van der Veen; F D Verbaak; D J Faber; T G van Leeuwen; T T J M Berendschot Journal: Eye (Lond) Date: 2010-11-05 Impact factor: 3.775
Authors: Robin G Abell; Alex W Hewitt; Marko Andric; Penelope L Allen; Nitin Verma Journal: Graefes Arch Clin Exp Ophthalmol Date: 2014-01-05 Impact factor: 3.117