Literature DB >> 19093716

Mechanism of action of homocysteine and its thiolactone in hemostasis system.

K Karolczak1, B Olas.   

Abstract

In the article, the actions of homocysteine (Hcys) and its metabolite - cyclic thioester - homocysteine thiolactone (HTL) on complex process of hemostasis, which regulates the flowing properties of blood, are described. Possible interaction of Hcys and HTL with endothelial cells, blood platelets, plasmatic fibrinogen and plasminogen, as the important major components of hemostasis are also discussed. The modification of hemostatic proteins (N-homocysteinylated or S-homocysteinylated proteins) induced by Hcys or its thiolactone, and links of homocysteine or homocysteine thiolactone to "NO metabolism seem to be the main reason of biotoxicty of homocysteine in cardiovascular diseases.

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Year:  2008        PMID： 19093716     DOI： 10.33549/physiolres.931566

Source DB:  PubMed          Journal:  Physiol Res        ISSN： 0862-8408            Impact factor:   1.881


  8 in total

1.  Comparison of the effect of homocysteine and its thiolactone on the fibrinolytic system using human plasma and purified plasminogen.

Authors:  Joanna Kołodziejczyk; Joanna Malinowska; Pawel Nowak; Beata Olas
Journal:  Mol Cell Biochem       Date:  2010-07-24       Impact factor: 3.396

2.  The polyphenol-rich extracts from black chokeberry and grape seeds impair changes in the platelet adhesion and aggregation induced by a model of hyperhomocysteinemia.

Authors:  Joanna Malinowska; Wieslaw Oleszek; Anna Stochmal; Beata Olas
Journal:  Eur J Nutr       Date:  2012-07-19       Impact factor: 5.614

3.  Acute hyperhomocysteinemia alters the coagulation system and oxidative status in the blood of rats.

Authors:  Aline A da Cunha; Emilene Scherer; Maira J da Cunha; Felipe Schmitz; Fernanda R Machado; Daniela D Lima; Débora Delwing; Angela T S Wyse
Journal:  Mol Cell Biochem       Date:  2011-09-23       Impact factor: 3.396

4.  Risk Factors of Ischemic Stroke in Young Adults: A Chinese Single-Center Study.

Authors:  Mingyu Tang; Guangsong Han; Ming Yao; Bin Peng; Yicheng Zhu; Lixin Zhou; Jun Ni
Journal:  Front Neurol       Date:  2022-05-18       Impact factor: 4.086

Review 5.  Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure-How Strong Is That Link?

Authors:  Zorislava Bajic; Tanja Sobot; Ranko Skrbic; Milos P Stojiljkovic; Nenad Ponorac; Amela Matavulj; Dragan M Djuric
Journal:  Biomolecules       Date:  2022-04-01

6.  Intravitreal homocysteine-thiolactone injection leads to the degeneration of multiple retinal cells, including photoreceptors.

Authors:  Han-Hsin Chang; David Pei-Cheng Lin; Ying-Shan Chen; Hsiang-Jui Liu; Wei Lin; Zih-Jay Tsao; Mei-Ching Teng; Bo-Yie Chen
Journal:  Mol Vis       Date:  2011-07-19       Impact factor: 2.367

7.  A surgical polypragmasy: Koninckx PR, Corona R, Timmerman D, Verguts J, Adamyan L. Peritoneal full-conditioning reduces postoperative adhesions and pain: a randomised controlled trial in deep endometriosis surgery. J Ovarian Res. 2013 Dec 11;6(1):90.

Authors:  Ospan A Mynbaev; Peter Biro; Marina Yu Eliseeva; Andrea Tinelli; Antonio Malvasi; Ioannis P Kosmas; Mykhailo V Medvediev; Tatiana I Babenko; Madina I Mazitova; Sergei S Simakov; Michael Stark
Journal:  J Ovarian Res       Date:  2014-03-10       Impact factor: 4.234

8.  Effects of Hyperhomocysteinemia on the Platelet-Driven Contraction of Blood Clots.

Authors:  Rustem I Litvinov; Alina D Peshkova; Giang Le Minh; Nail N Khaertdinov; Natalia G Evtugina; Guzel F Sitdikova; John W Weisel
Journal:  Metabolites       Date:  2021-06-01
  8 in total

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