BACKGROUND: Natural killer (NK)-like T cells comprising CD56(+) T cells and CD57(+) T cells belong to a subset of CD1d-independent NKT cells playing an important role in regulating immune responses. Although NK-like T cells are reported to increase in patients with advanced gastric carcinomas, it remains unknown how NK-like T cells are involved in disease progression in gastric cancer patients. METHODS: The proportions of Th1 cells (interferon [IFN]-gamma-producing CD4(+) T cells), Th2 cells (IL-4-producing CD4(+) T cells), and NK-like T cells (CD56(+) T cells and CD57(+) T cells) in the peripheral blood of 48 gastric cancer patients and 20 healthy controls were measured by two-color flow cytometry analysis and by intracellular cytokine analysis to investigate an association of these immune cells with the survival rate of gastric cancer patients. RESULTS: Univariate analysis showed that Th1 cells and CD57(+) T cells, as well as some clinicopathological factors, significantly influenced the survival rate. CD57-high (> or ==18%) patients survived for a significantly shorter period after surgery compared to CD57-low patients (P = 0.046; Kaplan-Meier, log-rank test) in the stage III-IV patients, but not in the stage I-II patients. Further, multivariate analysis showed that lymphatic invasion was a statistically significant independent risk factor in all the gastric cancer patients, but the proportion of CD57(+) T cells as well as depth of tumor were statistically significant independent risk factors in patients with advanced carcinomas (stage III-IV). CONCLUSION: An increased proportion (> or ==18%) of CD57(+) T cells in the peripheral blood of patients with advanced gastric carcinomas could indicate a poor prognosis.
BACKGROUND: Natural killer (NK)-like T cells comprising CD56(+) T cells and CD57(+) T cells belong to a subset of CD1d-independent NKT cells playing an important role in regulating immune responses. Although NK-like T cells are reported to increase in patients with advanced gastric carcinomas, it remains unknown how NK-like T cells are involved in disease progression in gastric cancerpatients. METHODS: The proportions of Th1 cells (interferon [IFN]-gamma-producing CD4(+) T cells), Th2 cells (IL-4-producing CD4(+) T cells), and NK-like T cells (CD56(+) T cells and CD57(+) T cells) in the peripheral blood of 48 gastric cancerpatients and 20 healthy controls were measured by two-color flow cytometry analysis and by intracellular cytokine analysis to investigate an association of these immune cells with the survival rate of gastric cancerpatients. RESULTS: Univariate analysis showed that Th1 cells and CD57(+) T cells, as well as some clinicopathological factors, significantly influenced the survival rate. CD57-high (> or ==18%) patients survived for a significantly shorter period after surgery compared to CD57-low patients (P = 0.046; Kaplan-Meier, log-rank test) in the stage III-IV patients, but not in the stage I-II patients. Further, multivariate analysis showed that lymphatic invasion was a statistically significant independent risk factor in all the gastric cancerpatients, but the proportion of CD57(+) T cells as well as depth of tumor were statistically significant independent risk factors in patients with advanced carcinomas (stage III-IV). CONCLUSION: An increased proportion (> or ==18%) of CD57(+) T cells in the peripheral blood of patients with advanced gastric carcinomas could indicate a poor prognosis.
Authors: B Reipert; C Scheuch; A Lukowsky; P Reinke; E Fietze; W D Döcke; G Staffa; S Czerlinksi; R Hetzer; H D Volk Journal: Clin Exp Immunol Date: 1992-07 Impact factor: 4.330
Authors: E Leroy; C F Calvo; M Divine; M F Gourdin; F Baujean; M H Ben Aribia; Z Mishal; J P Vernant; J P Farcet; A Senik Journal: J Immunol Date: 1986-10-01 Impact factor: 5.422
Authors: M Satoh; S Seki; W Hashimoto; K Ogasawara; T Kobayashi; K Kumagai; S Matsuno; K Takeda Journal: J Immunol Date: 1996-11-01 Impact factor: 5.422
Authors: A Dupuy d'Angeac; S Monier; C Jorgensen; Q Gao; A Travaglio-Encinoza; C Bologna; B Combe; J Sany; T Rème Journal: Arthritis Rheum Date: 1993-05
Authors: Richard C Wu; Shujuan Liu; Jessica A Chacon; Sheng Wu; Yufeng Li; Pariya Sukhumalchandra; James L Murray; Jeffrey J Molldrem; Patrick Hwu; Hanspeter Pircher; Gregory Lizée; Laszlo G Radvanyi Journal: Clin Cancer Res Date: 2012-02-03 Impact factor: 12.531