OBJECTIVE: We determined the autoantibody profile in autoimmune thyroid diseases (AITD) and examined the distribution of thyroid-related autoantibodies in other autoimmune disorders. METHODS: We tested sera from 234 patients with Graves' disease (GD), 130 with Hashimoto's thyroiditis (HT), 249 with other autoimmune diseases, and 50 healthy controls by enzyme-linked immunosorbent assay or radioimmunoassay. RESULTS: Autoantibodies except TSH receptor antibody (Ab), anti-thyroglobulin (Tg) Ab and anti-thyroid peroxidase (TPO) Ab were not significantly prevalent in patients with AITD despite a significantly high elevation of thyroid-related Ab. Significant prevalence of autoantibodies related to AITD was observed in type 1 diabetes patients. Elevation of anti-Tg Ab was seen in patients with primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH), and anti-TPO Ab was elevated in patients with PBC. Although the prevalence of anti-acetylcholine receptor Ab and systemic lupus erythematosus (SLE)- related Ab was significant in AIH, primary Sjögren's syndrome (pSS)-related Ab were also found in both liver diseases. In myasthenia gravis (MG) patients, thyroid-related Ab and pSS-related Ab were detected in both MG groups, although SLE-related Ab were limited to the anti-muscle specific kinase Ab-positive MG patients. In patients with connective tissue diseases, anti- Tg Ab and anti-TPO Ab were significantly prevalent. CONCLUSION: Thyroid-related Ab were significantly elevated in all autoimmune diseases. Conversely, the elevations of Ab were not significant in the patients with AITD, suggesting a close relationship between AITD and other immune-mediated diseases.
OBJECTIVE: We determined the autoantibody profile in autoimmune thyroid diseases (AITD) and examined the distribution of thyroid-related autoantibodies in other autoimmune disorders. METHODS: We tested sera from 234 patients with Graves' disease (GD), 130 with Hashimoto's thyroiditis (HT), 249 with other autoimmune diseases, and 50 healthy controls by enzyme-linked immunosorbent assay or radioimmunoassay. RESULTS: Autoantibodies except TSH receptor antibody (Ab), anti-thyroglobulin (Tg) Ab and anti-thyroid peroxidase (TPO) Ab were not significantly prevalent in patients with AITD despite a significantly high elevation of thyroid-related Ab. Significant prevalence of autoantibodies related to AITD was observed in type 1 diabetespatients. Elevation of anti-Tg Ab was seen in patients with primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH), and anti-TPO Ab was elevated in patients with PBC. Although the prevalence of anti-acetylcholine receptor Ab and systemic lupus erythematosus (SLE)- related Ab was significant in AIH, primary Sjögren's syndrome (pSS)-related Ab were also found in both liver diseases. In myasthenia gravis (MG) patients, thyroid-related Ab and pSS-related Ab were detected in both MG groups, although SLE-related Ab were limited to the anti-muscle specific kinase Ab-positive MGpatients. In patients with connective tissue diseases, anti- Tg Ab and anti-TPO Ab were significantly prevalent. CONCLUSION: Thyroid-related Ab were significantly elevated in all autoimmune diseases. Conversely, the elevations of Ab were not significant in the patients with AITD, suggesting a close relationship between AITD and other immune-mediated diseases.
Authors: N Sera; A Kawakami; T Nakashima; H Nakamura; M Imaizumi; T Koji; Y Abe; T Usa; T Tominaga; E Ejima; K Ashizawa; N Yokoyama; N Ishikawa; K Ito; K Eguchi Journal: Clin Exp Immunol Date: 2001-05 Impact factor: 4.330
Authors: E Kawasaki; L Yu; R Gianani; C F Verge; S Babu; E Bonifacio; G S Eisenbarth Journal: J Clin Endocrinol Metab Date: 1997-02 Impact factor: 5.958
Authors: T Kobayashi; K Tamemoto; K Nakanishi; N Kato; M Okubo; H Kajio; T Sugimoto; T Murase; K Kosaka Journal: Diabetes Care Date: 1993-05 Impact factor: 19.112
Authors: E Kawasaki; N Abiru; M Yano; S Uotani; K Matsumoto; H Matsuo; H Yamasaki; H Yamamoto; Y Yamaguchi; S Akazawa Journal: J Autoimmun Date: 1995-10 Impact factor: 7.094
Authors: K Beever; J Bradbury; D Phillips; S M McLachlan; C Pegg; A Goral; W Overbeck; G Feifel; B R Smith Journal: Clin Chem Date: 1989-09 Impact factor: 8.327
Authors: M I Leite; E Coutinho; M Lana-Peixoto; S Apostolos; P Waters; D Sato; L Melamud; M Marta; A Graham; J Spillane; A M Villa; D Callegaro; E Santos; A Martins da Silva; S Jarius; R Howard; I Nakashima; G Giovannoni; C Buckley; D Hilton-Jones; A Vincent; J Palace Journal: Neurology Date: 2012-05-02 Impact factor: 9.910