Literature DB >> 19091994

Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques.

Michael D George1, David Verhoeven, Sumathi Sankaran, Tiffany Glavan, Elizabeth Reay, Satya Dandekar.   

Abstract

Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4(+) T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene transcription, demonstrating the rapid establishment of pathogenesis in the oral mucosa.

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Year:  2008        PMID： 19091994      PMCID： PMC2643550          DOI： 10.1128/CVI.00265-08

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  23 in total

1.  Mucosal phenotype of antiviral cytotoxic T lymphocytes in the vaginal mucosa of SIV-infected rhesus macaques.

Authors:  M B McChesney; J R Collins; C J Miller
Journal:  AIDS Res Hum Retroviruses       Date:  1998-04       Impact factor: 2.205

2.  Gene expression profiling of gut mucosa and mesenteric lymph nodes in simian immunodeficiency virus-infected macaques with divergent disease course.

Authors:  M D George; D Verhoeven; Z McBride; S Dandekar
Journal:  J Med Primatol       Date:  2006-08       Impact factor: 0.667

3.  Rapid virus dissemination in infant macaques after oral simian immunodeficiency virus exposure in the presence of local innate immune responses.

Authors:  Kristina Abel; Bapi Pahar; Koen K A Van Rompay; Linda Fritts; Clarissa Sin; Kimberli Schmidt; Roxana Colón; Mike McChesney; Marta L Marthas
Journal:  J Virol       Date:  2006-07       Impact factor: 5.103

4.  Perforin expression in the gastrointestinal mucosa is limited to acute simian immunodeficiency virus infection.

Authors:  Máire F Quigley; Kristina Abel; Bartek Zuber; Christopher J Miller; Johan K Sandberg; Barbara L Shacklett
Journal:  J Virol       Date:  2006-03       Impact factor: 5.103

5.  Early antiretroviral therapy for simian immunodeficiency virus infection leads to mucosal CD4+ T-cell restoration and enhanced gene expression regulating mucosal repair and regeneration.

Authors:  Michael D George; Elizabeth Reay; Sumathi Sankaran; Satya Dandekar
Journal:  J Virol       Date:  2005-03       Impact factor: 5.103

Review 6.  Oral mucosal immunity and HIV/SIV infection.

Authors:  F X Lü; R S Jacobson
Journal:  J Dent Res       Date:  2007-03       Impact factor: 6.116

7.  Rapid onset of intestinal epithelial barrier dysfunction in primary human immunodeficiency virus infection is driven by an imbalance between immune response and mucosal repair and regeneration.

Authors:  Sumathi Sankaran; Michael D George; Elizabeth Reay; Moraima Guadalupe; Jason Flamm; Thomas Prindiville; Satya Dandekar
Journal:  J Virol       Date:  2007-10-24       Impact factor: 5.103

8.  Simian immunodeficiency virus infection induces severe loss of intestinal central memory T cells which impairs CD4+ T-cell restoration during antiretroviral therapy.

Authors:  D Verhoeven; S Sankaran; S Dandekar
Journal:  J Med Primatol       Date:  2007-08       Impact factor: 0.667

9.  Gastrointestinal T lymphocytes retain high potential for cytokine responses but have severe CD4(+) T-cell depletion at all stages of simian immunodeficiency virus infection compared to peripheral lymphocytes.

Authors:  Z Smit-McBride; J J Mattapallil; M McChesney; D Ferrick; S Dandekar
Journal:  J Virol       Date:  1998-08       Impact factor: 5.103

10.  Mucosal innate immune response associated with a timely humoral immune response and slower disease progression after oral transmission of simian immunodeficiency virus to rhesus macaques.

Authors:  Jeffrey M Milush; Kelly Stefano-Cole; Kimberli Schmidt; Andre Durudas; Ivona Pandrea; Donald L Sodora
Journal:  J Virol       Date:  2007-04-11       Impact factor: 5.103
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  7 in total

Review 1.  Microbiome in human immunodeficiency virus infection.

Authors:  January T Salas; Theresa L Chang
Journal:  Clin Lab Med       Date:  2014-09-18       Impact factor: 1.935

2.  Innate immunity including epithelial and nonspecific host factors: workshop 1B.

Authors:  A Weinberg; J R Naglik; A Kohli; S M Tugizov; P L Fidel; Y Liu; M Herzberg
Journal:  Adv Dent Res       Date:  2011-04

3.  Transcription profiling reveals potential mechanisms of dysbiosis in the oral microbiome of rhesus macaques with chronic untreated SIV infection.

Authors:  Susan Ocon; Christina Murphy; Angeline T Dang; Sumathi Sankaran-Walters; Chin-Shang Li; Ross Tarara; Niku Borujerdpur; Satya Dandekar; Bruce J Paster; Michael D George
Journal:  PLoS One       Date:  2013-11-29       Impact factor: 3.240

4.  Evidence of an increased pathogenic footprint in the lingual microbiome of untreated HIV infected patients.

Authors:  Angeline T Dang; Sean Cotton; Sumathi Sankaran-Walters; Chin-Shang Li; Chia-Yuan Michael Lee; Satya Dandekar; Bruce J Paster; Michael D George
Journal:  BMC Microbiol       Date:  2012-07-28       Impact factor: 3.605

5.  Functional perturbation of classical natural killer and innate lymphoid cells in the oral mucosa during SIV infection.

Authors:  Haiying Li; R Keith Reeves
Journal:  Front Immunol       Date:  2013-01-08       Impact factor: 7.561

6.  Toll mediated infection response is altered by gravity and spaceflight in Drosophila.

Authors:  Katherine Taylor; Kurt Kleinhesselink; Michael D George; Rachel Morgan; Tangi Smallwood; Ann S Hammonds; Patrick M Fuller; Perot Saelao; Jeff Alley; Allen G Gibbs; Deborah K Hoshizaki; Laurence von Kalm; Charles A Fuller; Kathleen M Beckingham; Deborah A Kimbrell
Journal:  PLoS One       Date:  2014-01-24       Impact factor: 3.240

7.  Long Term Delta-9-tetrahydrocannabinol Administration Inhibits Proinflammatory Responses in Minor Salivary Glands of Chronically Simian Immunodeficieny Virus Infected Rhesus Macaques.

Authors:  Xavier Alvarez; Karol Sestak; Siddappa N Byrareddy; Mahesh Mohan
Journal:  Viruses       Date:  2020-07-01       Impact factor: 5.818
  7 in total

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