Kenji Yamashiro1,2,3, Akitaka Tsujikawa4, Akihiro Nishida5,6, Michiko Mandai5,7, Yasuo Kurimoto5,6. 1. Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan. yamashro@kuhp.kyoto-u.ac.jp. 2. Department of Regenerative Medicine, Institute of Biomedical Research and Innovation, Kobe, Japan. yamashro@kuhp.kyoto-u.ac.jp. 3. RIKEN Center for Developmental Biology, Kobe, Japan. yamashro@kuhp.kyoto-u.ac.jp. 4. Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. 5. Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan. 6. Department of Regenerative Medicine, Institute of Biomedical Research and Innovation, Kobe, Japan. 7. RIKEN Center for Developmental Biology, Kobe, Japan.
Abstract
PURPOSE: To evaluate the recurrence of polypoidal lesions after photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV). METHODS: This is a retrospective review of data on 28 patients with PCV treated with PDT. The recurrent polypoidal lesions were observed with fluorescein and indocyanine green angiography. RESULTS: In 26 of the 28 eyes the PCV remained inactive for more than 12 months after one to three treatments with PDT. Recurrence of the polypoidal lesions after more than a 12-month inactive period was reported in eight eyes: three at 15 months, two at 18 months, and three at 21 months. Kaplan-Meier estimates of recurrence were 11.5% at 15 months, 20.4% at 18 months, and 38.8% at 21 months, with no subsequent recurrence until passage of 36 months of inactivity after the last PDT. Additional PDT after recurrence improved or preserved visual acuity in 80% of those treated compared to the visual acuity before the first PDT. CONCLUSIONS: Recurrence of PCV occurs in about 40% of eyes treated for PCV even after a long period of inactivity, so careful follow-up is needed.
PURPOSE: To evaluate the recurrence of polypoidal lesions after photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV). METHODS: This is a retrospective review of data on 28 patients with PCV treated with PDT. The recurrent polypoidal lesions were observed with fluorescein and indocyanine green angiography. RESULTS: In 26 of the 28 eyes the PCV remained inactive for more than 12 months after one to three treatments with PDT. Recurrence of the polypoidal lesions after more than a 12-month inactive period was reported in eight eyes: three at 15 months, two at 18 months, and three at 21 months. Kaplan-Meier estimates of recurrence were 11.5% at 15 months, 20.4% at 18 months, and 38.8% at 21 months, with no subsequent recurrence until passage of 36 months of inactivity after the last PDT. Additional PDT after recurrence improved or preserved visual acuity in 80% of those treated compared to the visual acuity before the first PDT. CONCLUSIONS: Recurrence of PCV occurs in about 40% of eyes treated for PCV even after a long period of inactivity, so careful follow-up is needed.
Authors: Rufino M Silva; João Figueira; M Luz Cachulo; Liliane Duarte; José R Faria de Abreu; J G Cunha-Vaz Journal: Graefes Arch Clin Exp Ophthalmol Date: 2005-10-20 Impact factor: 3.117