Apurva N Trivedi1, Edward A Levine, Girish Mishra. 1. Section of Gastroenterology, Wake Forest University Baptist Medical Center, Medical Center Blvd, Winston-Salem, NC 27157, USA.
Abstract
INTRODUCTION: Appendiceal tumors represent a subset of colonic neoplasms that frequently defy early diagnosis only to present at advanced stage with peritoneal metastasis. Data on early detection by colonoscopy is limited to case reports or series. The aim of this study is to determine the diagnostic yield of colonoscopy in detecting appendiceal lesions in patients with appendiceal adenocarcinoma and pseudomyxoma peritonei. METHODS: We reviewed clinicopathologic data on 121 consecutive patients with histologically confirmed appendiceal adenocarcinoma with pseudomyxoma peritonei presenting to our institution for intraperitoneal hyperthermic chemotherapy (IPHC) and cytoreductive surgery between February, 1993 and August, 2007, focusing on the colonoscopy findings. RESULTS: Preoperative colonoscopic data were available on 64 patients (average age = 51; 52 for IPHC patients). Abnormal findings included seven patients with appendiceal lesions (11%), 12 patients with cecal abnormalities (19%), and 28 patients with polyps (44%). Twenty-three patients (36%) had a normal colonoscopy. Malignancy was documented in two of the 64 (3.1%) patients on preoperative colonoscopy biopsies. CONCLUSIONS: Appendiceal abnormalities are infrequently seen on colonoscopy and rarely yield a diagnostic biopsy in patients with appendiceal carcinoma. We found that nearly 42% of patients with carcinoma of the appendix have synchronous colonic polyps, a much higher prevalence than would be expected, supporting a role for a perioperative colonoscopy.
INTRODUCTION:Appendiceal tumors represent a subset of colonic neoplasms that frequently defy early diagnosis only to present at advanced stage with peritoneal metastasis. Data on early detection by colonoscopy is limited to case reports or series. The aim of this study is to determine the diagnostic yield of colonoscopy in detecting appendiceal lesions in patients with appendiceal adenocarcinoma and pseudomyxoma peritonei. METHODS: We reviewed clinicopathologic data on 121 consecutive patients with histologically confirmed appendiceal adenocarcinoma with pseudomyxoma peritonei presenting to our institution for intraperitoneal hyperthermic chemotherapy (IPHC) and cytoreductive surgery between February, 1993 and August, 2007, focusing on the colonoscopy findings. RESULTS: Preoperative colonoscopic data were available on 64 patients (average age = 51; 52 for IPHC patients). Abnormal findings included seven patients with appendiceal lesions (11%), 12 patients with cecal abnormalities (19%), and 28 patients with polyps (44%). Twenty-three patients (36%) had a normal colonoscopy. Malignancy was documented in two of the 64 (3.1%) patients on preoperative colonoscopy biopsies. CONCLUSIONS:Appendiceal abnormalities are infrequently seen on colonoscopy and rarely yield a diagnostic biopsy in patients with appendiceal carcinoma. We found that nearly 42% of patients with carcinoma of the appendix have synchronous colonic polyps, a much higher prevalence than would be expected, supporting a role for a perioperative colonoscopy.
Authors: N Mizuma; T Kabemura; K Akahoshi; D Yasuda; H Okabe; Y Chijiiwa; H Nawata; N Matsui Journal: Gastrointest Endosc Date: 1997-12 Impact factor: 9.427
Authors: Joseph Misdraji; Rhonda K Yantiss; Fiona M Graeme-Cook; Ulysses J Balis; Robert H Young Journal: Am J Surg Pathol Date: 2003-08 Impact factor: 6.394
Authors: Edward A Levine; Konstantinos I Votanopoulos; Shadi A Qasem; John Philip; Kathleen A Cummins; Jeff W Chou; Jimmy Ruiz; Ralph D'Agostino; Perry Shen; Lance D Miller Journal: J Am Coll Surg Date: 2015-12-21 Impact factor: 6.113
Authors: Jing Su; Guangxu Jin; Konstantinos I Votanopoulos; Lou Craddock; Perry Shen; Jeff W Chou; Shadi Qasem; Stacey S O'Neill; Kathleen Cummins Perry; Lance D Miller; Edward A Levine Journal: Ann Surg Oncol Date: 2020-01-24 Impact factor: 5.344
Authors: Edward A Levine; Konstantinos I Votanopoulos; Perry Shen; Greg Russell; Joyce Fenstermaker; Paul Mansfield; David Bartlett; John H Stewart Journal: J Am Coll Surg Date: 2018-01-10 Impact factor: 6.113