Literature DB >> 19089377

Isolation and purification of antigenic components of Cryptococcus.

Karen L Wozniak1, Stuart M Levitz.   

Abstract

The encapsulated fungal pathogens Cryptococcus neoformans and Cryptococcus gattii are significant agents of life-threatening infections, particularly in persons with suppressed cell-mediated immunity. This chapter provides detailed methodology for the purification of two of the major antigen fractions of C. neoformans: glucuronoxylomannan (GXM) and mannoprotein (MP). GXM is the primary component of the polysaccharide capsule, which is the major cryptococcal virulence factor. In contrast, MPs have been identified as key antigens that stimulate T-cell responses. Purification of GXM and MP should assist investigators studying the antigenic, biochemical, and virulence properties of Cryptococcus species.

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Year:  2009        PMID： 19089377      PMCID： PMC3297022          DOI： 10.1007/978-1-59745-204-5_7

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  49 in total

1.  Potent inhibition of neutrophil migration by cryptococcal mannoprotein-4-induced desensitization.

Authors:  F E Coenjaerts; A M Walenkamp; P N Mwinzi; J Scharringa; H A Dekker; J A van Strijp; R Cherniak; A I Hoepelman
Journal:  J Immunol       Date:  2001-10-01       Impact factor: 5.422

2.  Differences in outcome of the interaction between Cryptococcus neoformans glucuronoxylomannan and human monocytes and neutrophils.

Authors:  Claudia Monari; Cinzia Retini; Arturo Casadevall; Dale Netski; Francesco Bistoni; Thomas R Kozel; Anna Vecchiarelli
Journal:  Eur J Immunol       Date:  2003-04       Impact factor: 5.532

3.  In vivo clearance of glucuronoxylomannan, the major capsular polysaccharide of Cryptococcus neoformans: a critical role for tissue macrophages.

Authors:  M Grinsell; L C Weinhold; J E Cutler; Y Han; T R Kozel
Journal:  J Infect Dis       Date:  2001-07-13       Impact factor: 5.226

4.  Role of mannoprotein in induction and regulation of immunity to Cryptococcus neoformans.

Authors:  D Pietrella; R Cherniak; C Strappini; S Perito; P Mosci; F Bistoni; A Vecchiarelli
Journal:  Infect Immun       Date:  2001-05       Impact factor: 3.441

5.  Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule.

Authors:  S Shoham; C Huang; J M Chen; D T Golenbock; S M Levitz
Journal:  J Immunol       Date:  2001-04-01       Impact factor: 5.422

6.  Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformans.

Authors:  S M Levitz; S Nong ; M K Mansour; C Huang; C A Specht
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-14       Impact factor: 11.205

7.  Cryptococcus gattii in wildlife of Vancouver Island, British Columbia, Canada.

Authors:  C Duncan; H Schwantje; C Stephen; J Campbell; K Bartlett
Journal:  J Wildl Dis       Date:  2006-01       Impact factor: 1.535

8.  Cas1p is a membrane protein necessary for the O-acetylation of the Cryptococcus neoformans capsular polysaccharide.

Authors:  G Janbon; U Himmelreich; F Moyrand; L Improvisi; F Dromer
Journal:  Mol Microbiol       Date:  2001-10       Impact factor: 3.501

9.  Purification and characterization of a second immunoreactive mannoprotein from Cryptococcus neoformans that stimulates T-Cell responses.

Authors:  Chao Huang; Shu-Hua Nong; Michael K Mansour; Charles A Specht; Stuart M Levitz
Journal:  Infect Immun       Date:  2002-10       Impact factor: 3.441

10.  Direct inhibition of T-cell responses by the Cryptococcus capsular polysaccharide glucuronoxylomannan.

Authors:  Lauren E Yauch; Jennifer S Lam; Stuart M Levitz
Journal:  PLoS Pathog       Date:  2006-11       Impact factor: 6.823
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  19 in total

1.  Characterization of IL-22 and antimicrobial peptide production in mice protected against pulmonary Cryptococcus neoformans infection.

Authors:  Karen L Wozniak; Camaron R Hole; Junko Yano; Paul L Fidel; Floyd L Wormley
Journal:  Microbiology (Reading)       Date:  2014-04-23       Impact factor: 2.777

2.  Selective expansion of polyfunctional pathogen-specific CD4(+) T cells in HIV-1-infected patients with immune reconstitution inflammatory syndrome.

Authors:  Yolanda D Mahnke; Jamieson H Greenwald; Rebecca DerSimonian; Gregg Roby; Lis R V Antonelli; Alan Sher; Mario Roederer; Irini Sereti
Journal:  Blood       Date:  2012-01-04       Impact factor: 22.113

3.  Unraveling unique structure and biosynthesis pathway of N-linked glycans in human fungal pathogen Cryptococcus neoformans by glycomics analysis.

Authors:  Jeong-Nam Park; Dong-Jik Lee; Ohsuk Kwon; Doo-Byoung Oh; Yong-Sun Bahn; Hyun Ah Kang
Journal:  J Biol Chem       Date:  2012-04-12       Impact factor: 5.157

4.  The Interaction of Pneumocystis with the C-Type Lectin Receptor Mincle Exerts a Significant Role in Host Defense against Infection.

Authors:  Theodore J Kottom; Deanne M Hebrink; Paige E Jenson; Vijayalakshmi Nandakumar; Marcel Wüthrich; Huafeng Wang; Bruce Klein; Sho Yamasaki; Bernd Lepenies; Andrew H Limper
Journal:  J Immunol       Date:  2017-03-15       Impact factor: 5.422

5.  Unraveling the novel structure and biosynthetic pathway of O-linked glycans in the Golgi apparatus of the human pathogenic yeast Cryptococcus neoformans.

Authors:  Dong-Jik Lee; Yong-Sun Bahn; Hong-Jin Kim; Seung-Yeon Chung; Hyun Ah Kang
Journal:  J Biol Chem       Date:  2014-12-04       Impact factor: 5.157

Review 6.  How sweet it is! Cell wall biogenesis and polysaccharide capsule formation in Cryptococcus neoformans.

Authors:  Tamara Lea Doering
Journal:  Annu Rev Microbiol       Date:  2009       Impact factor: 15.500

7.  Cryptococcosis-IRIS is associated with lower cryptococcus-specific IFN-γ responses before antiretroviral therapy but not higher T-cell responses during therapy.

Authors:  Christina C Chang; Andrew Lim; Saleha Omarjee; Stuart M Levitz; Bernadett I Gosnell; Tim Spelman; Julian H Elliott; William H Carr; Mohamed-Yunus S Moosa; Thumbi Ndung'u; Sharon R Lewin; Martyn A French
Journal:  J Infect Dis       Date:  2013-06-12       Impact factor: 5.226

8.  Dectin-2 Is a C-Type Lectin Receptor that Recognizes Pneumocystis and Participates in Innate Immune Responses.

Authors:  Theodore J Kottom; Deanne M Hebrink; Paige E Jenson; Paige L Marsolek; Marcel Wüthrich; Huafeng Wang; Bruce Klein; Sho Yamasaki; Andrew H Limper
Journal:  Am J Respir Cell Mol Biol       Date:  2018-02       Impact factor: 6.914

Review 9.  Unraveling synthesis of the cryptococcal cell wall and capsule.

Authors:  Zhuo A Wang; Lucy X Li; Tamara L Doering
Journal:  Glycobiology       Date:  2018-10-01       Impact factor: 4.313

10.  The phenotype of the Cryptococcus-specific CD4+ memory T-cell response is associated with disease severity and outcome in HIV-associated cryptococcal meningitis.

Authors:  Joseph N Jarvis; Joseph P Casazza; Hunter H Stone; Graeme Meintjes; Stephen D Lawn; Stuart M Levitz; Thomas S Harrison; Richard A Koup
Journal:  J Infect Dis       Date:  2013-03-14       Impact factor: 5.226
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