BACKGROUND: Limited clinical data suggest that chronic Trypanosoma cruzi infection, which causes Chagas' disease (ChD), is associated with cognitive impairment. This study investigated this association in a large population-based sample of older adults. METHODS: Participants in this cross-sectional study comprised 1,449 persons aged > or = 60 years from a Brazilian endemic area (Bambuí). Cognitive functioning was ascertained by the Mini-Mental State Examination (MMSE), considering its score in percentiles [< or =14 (<5th percentile), 15-22 (5th to <25th) and > or =23]. Hypothesized risk factors were T. cruzi infection, ChD-related electrocardiographic (ECG) abnormalities and use of digoxin medication. Potential confounders included depressive symptoms, smoking, stroke, hemoglobin, HDL cholesterol, blood glucose, systolic blood pressure, and use of psychoactive medication. RESULTS: The prevalence of T. cruzi infection was 37.6%. There was a graded and independent association between infection and the MMSE score (adjusted odds ratios estimated by ordinal logistic regression = 1.99; 95% CI 1.43-2.76). No significant associations between the MMSE score and ECG abnormalities or digoxin medication use were found. CONCLUSIONS: This study provides for the first time epidemiological evidence of an association between T. cruzi infection and cognitive impairment which was not mediated by either ChD-related ECG abnormalities or digoxin medication use. 2008 S. Karger AG, Basel.
BACKGROUND: Limited clinical data suggest that chronic Trypanosoma cruzi infection, which causes Chagas' disease (ChD), is associated with cognitive impairment. This study investigated this association in a large population-based sample of older adults. METHODS:Participants in this cross-sectional study comprised 1,449 persons aged > or = 60 years from a Brazilian endemic area (Bambuí). Cognitive functioning was ascertained by the Mini-Mental State Examination (MMSE), considering its score in percentiles [< or =14 (<5th percentile), 15-22 (5th to <25th) and > or =23]. Hypothesized risk factors were T. cruzi infection, ChD-related electrocardiographic (ECG) abnormalities and use of digoxin medication. Potential confounders included depressive symptoms, smoking, stroke, hemoglobin, HDL cholesterol, blood glucose, systolic blood pressure, and use of psychoactive medication. RESULTS: The prevalence of T. cruzi infection was 37.6%. There was a graded and independent association between infection and the MMSE score (adjusted odds ratios estimated by ordinal logistic regression = 1.99; 95% CI 1.43-2.76). No significant associations between the MMSE score and ECG abnormalities or digoxin medication use were found. CONCLUSIONS: This study provides for the first time epidemiological evidence of an association between T. cruzi infection and cognitive impairment which was not mediated by either ChD-related ECG abnormalities or digoxin medication use. 2008 S. Karger AG, Basel.
Authors: J O Lázzari; M Pereira; C M Antunes; A Guimarães; A Moncayo; R Chávez Domínguez; O Hernández Pieretti; V Macedo; A Rassi; J Maguire; A Romero Journal: Rev Panam Salud Publica Date: 1998-11
Authors: Francisco Javier Carod-Artal; Antonio Pedro Vargas; Thomas Anthony Horan; Luiz Guillerme Nadal Nunes Journal: Stroke Date: 2005-04-21 Impact factor: 7.914
Authors: Antonia Pino-Marín; Germán José Medina-Rincón; Sebastian Gallo-Bernal; Alejandro Duran-Crane; Álvaro Ignacio Arango Duque; María Juliana Rodríguez; Ramón Medina-Mur; Frida T Manrique; Julian F Forero; Hector M Medina Journal: Pathogens Date: 2021-04-22
Authors: Roberto M Saraiva; Mauro Felippe F Mediano; Fernanda Sns Mendes; Gilberto Marcelo Sperandio da Silva; Henrique H Veloso; Luiz Henrique C Sangenis; Paula Simplício da Silva; Flavia Mazzoli-Rocha; Andréa S Sousa; Marcelo T Holanda; Alejandro M Hasslocher-Moreno Journal: World J Cardiol Date: 2021-12-26
Authors: Jamary Oliveira-Filho; Jesângeli de S Dias; Pedro A P Jesus; Nestor J S B Neto; Roque Aras; Francisco J F B Reis; Karen L Furie Journal: Dement Neuropsychol Date: 2012 Jul-Sep