Literature DB >> 19088318

L-valine production during growth of pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator SugR.

Bastian Blombach1, Annette Arndt, Marc Auchter, Bernhard J Eikmanns.   

Abstract

Pyruvate dehydrogenase complex-deficient strains of Corynebacterium glutamicum produce L-valine from glucose only after depletion of the acetate required for growth. Here we show that inactivation of the DeoR-type transcriptional regulator SugR or replacement of acetate by ethanol already in course of the growth phase results in efficient L-valine production.

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Year:  2008        PMID： 19088318      PMCID： PMC2643581          DOI： 10.1128/AEM.02351-08

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  13 in total

Review 1.  Biotechnological production of amino acids and derivatives: current status and prospects.

Authors:  Wolfgang Leuchtenberger; Klaus Huthmacher; Karlheinz Drauz
Journal:  Appl Microbiol Biotechnol       Date:  2005-10-20       Impact factor: 4.813

Review 2.  Systems biology for industrial strains and fermentation processes--example: amino acids.

Authors:  R Takors; B Bathe; M Rieping; S Hans; R Kelle; K Huthmacher
Journal:  J Biotechnol       Date:  2007-02-11       Impact factor: 3.307

3.  Transcriptionally regulated adhA gene encodes alcohol dehydrogenase required for ethanol and n-propanol utilization in Corynebacterium glutamicum R.

Authors:  Anna Kotrbova-Kozak; Pavel Kotrba; Masayuki Inui; Jiri Sajdok; Hideaki Yukawa
Journal:  Appl Microbiol Biotechnol       Date:  2007-07-24       Impact factor: 4.813

4.  Quantitative determination of metabolic fluxes during coutilization of two carbon sources: comparative analyses with Corynebacterium glutamicum during growth on acetate and/or glucose.

Authors:  V F Wendisch; A A de Graaf; H Sahm; B J Eikmanns
Journal:  J Bacteriol       Date:  2000-06       Impact factor: 3.490

5.  L-valine production with pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum.

Authors:  Bastian Blombach; Mark E Schreiner; Jirí Holátko; Tobias Bartek; Marco Oldiges; Bernhard J Eikmanns
Journal:  Appl Environ Microbiol       Date:  2007-02-09       Impact factor: 4.792

6.  The DeoR-type regulator SugR represses expression of ptsG in Corynebacterium glutamicum.

Authors:  Verena Engels; Volker F Wendisch
Journal:  J Bacteriol       Date:  2007-02-09       Impact factor: 3.490

7.  Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation.

Authors:  Jin Hwan Park; Kwang Ho Lee; Tae Yong Kim; Sang Yup Lee
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-26       Impact factor: 11.205

8.  Ethanol catabolism in Corynebacterium glutamicum.

Authors:  Annette Arndt; Marc Auchter; Takeru Ishige; Volker F Wendisch; Bernhard J Eikmanns
Journal:  J Mol Microbiol Biotechnol       Date:  2007-08-13

9.  The alcohol dehydrogenase gene adhA in Corynebacterium glutamicum is subject to carbon catabolite repression.

Authors:  Annette Arndt; Bernhard J Eikmanns
Journal:  J Bacteriol       Date:  2007-08-10       Impact factor: 3.490

10.  Regulation of expression of general components of the phosphoenolpyruvate: carbohydrate phosphotransferase system (PTS) by the global regulator SugR in Corynebacterium glutamicum.

Authors:  Yuya Tanaka; Haruhiko Teramoto; Masayuki Inui; Hideaki Yukawa
Journal:  Appl Microbiol Biotechnol       Date:  2008-01-09       Impact factor: 4.813
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  18 in total

1.  Increased glucose utilization in Corynebacterium glutamicum by use of maltose, and its application for the improvement of L-valine productivity.

Authors:  Felix S Krause; Alexander Henrich; Bastian Blombach; Reinhard Krämer; Bernhard J Eikmanns; Gerd M Seibold
Journal:  Appl Environ Microbiol       Date:  2009-10-30       Impact factor: 4.792

2.  Corynebacterium glutamicum tailored for efficient isobutanol production.

Authors:  Bastian Blombach; Tanja Riester; Stefan Wieschalka; Christian Ziert; Jung-Won Youn; Volker F Wendisch; Bernhard J Eikmanns
Journal:  Appl Environ Microbiol       Date:  2011-03-25       Impact factor: 4.792

3.  Improvement of L-valine production at high temperature in Brevibacterium flavum by overexpressing ilvEBNrC genes.

Authors:  Xiaohu Hou; Xiangyang Ge; Di Wu; He Qian; Weiguo Zhang
Journal:  J Ind Microbiol Biotechnol       Date:  2011-06-25       Impact factor: 3.346

4.  Enhanced Glucose Consumption and Organic Acid Production by Engineered Corynebacterium glutamicum Based on Analysis of a pfkB1 Deletion Mutant.

Authors:  Satoshi Hasegawa; Yuya Tanaka; Masako Suda; Toru Jojima; Masayuki Inui
Journal:  Appl Environ Microbiol       Date:  2017-01-17       Impact factor: 4.792

5.  Platform engineering of Corynebacterium glutamicum with reduced pyruvate dehydrogenase complex activity for improved production of L-lysine, L-valine, and 2-ketoisovalerate.

Authors:  Jens Buchholz; Andreas Schwentner; Britta Brunnenkan; Christina Gabris; Simon Grimm; Robert Gerstmeir; Ralf Takors; Bernhard J Eikmanns; Bastian Blombach
Journal:  Appl Environ Microbiol       Date:  2013-07-08       Impact factor: 4.792

6.  Impact of CO2/HCO3 - Availability on Anaplerotic Flux in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains.

Authors:  Aileen Krüger; Johanna Wiechert; Cornelia Gätgens; Tino Polen; Regina Mahr; Julia Frunzke
Journal:  J Bacteriol       Date:  2019-09-20       Impact factor: 3.490

7.  Maltose uptake by the novel ABC transport system MusEFGK2I causes increased expression of ptsG in Corynebacterium glutamicum.

Authors:  Alexander Henrich; Nora Kuhlmann; Alexander W Eck; Reinhard Krämer; Gerd M Seibold
Journal:  J Bacteriol       Date:  2013-03-29       Impact factor: 3.490

8.  3-Methyl-1-butanol Biosynthesis in an Engineered Corynebacterium glutamicum.

Authors:  Shiyuan Xiao; Jingliang Xu; Xiaoyan Chen; Xiekun Li; Yu Zhang; Zhenhong Yuan
Journal:  Mol Biotechnol       Date:  2016-05       Impact factor: 2.695

9.  Metabolic engineering of Corynebacterium glutamicum for 2-ketoisovalerate production.

Authors:  Felix S Krause; Bastian Blombach; Bernhard J Eikmanns
Journal:  Appl Environ Microbiol       Date:  2010-10-08       Impact factor: 4.792

10.  Involvement of regulatory interactions among global regulators GlxR, SugR, and RamA in expression of ramA in Corynebacterium glutamicum.

Authors:  Koichi Toyoda; Haruhiko Teramoto; Wataru Gunji; Masayuki Inui; Hideaki Yukawa
Journal:  J Bacteriol       Date:  2013-02-08       Impact factor: 3.490
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