Literature DB >> 19087120

The role of the newer antiepileptic drugs in the treatment of generalized convulsive status epilepticus.

James W Wheless1, David M Treiman.   

Abstract

The emergency treatment of seizures is an important practical issue, especially the treatment of generalized convulsive status epilepticus (GCSE). Benzodiazepines or older standard antiepileptic drugs (phenobarbital, phenytoin) have typically been used as initial intravenous treatment of GCSE. As new parenteral antiepileptic drugs are developed, and more are on the horizon, questions are raised regarding their role in the treatment of status epilepticus (SE). This review discusses the evidence for the treatment of GCSE, including the newer agents (valproate, levetiracetam). We correlate the treatment of SE with our modern understanding of the underlying neurophysiology and seizure duration.

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Year:  2008        PMID： 19087120     DOI： 10.1111/j.1528-1167.2008.01929.x

Source DB:  PubMed          Journal:  Epilepsia        ISSN： 0013-9580            Impact factor:   5.864


  6 in total

1.  Status epilepticus: current treatment strategies.

Authors:  Edward M Manno
Journal:  Neurohospitalist       Date:  2011-01

2.  Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.

Authors:  Doodipala Samba Reddy; Marcus Zaayman; Ramkumar Kuruba; Xin Wu
Journal:  Neuropharmacology       Date:  2021-04-18       Impact factor: 5.273

Review 3.  Experimental models of status epilepticus and neuronal injury for evaluation of therapeutic interventions.

Authors:  Doodipala Samba Reddy; Ramkumar Kuruba
Journal:  Int J Mol Sci       Date:  2013-09-05       Impact factor: 5.923

4.  A multicentre randomised controlled trial of levetiracetam versus phenytoin for convulsive status epilepticus in children (protocol): Convulsive Status Epilepticus Paediatric Trial (ConSEPT) - a PREDICT study.

Authors:  Stuart R Dalziel; Jeremy Furyk; Megan Bonisch; Ed Oakley; Meredith Borland; Jocelyn Neutze; Susan Donath; Cynthia Sharpe; Simon Harvey; Andrew Davidson; Simon Craig; Natalie Phillips; Shane George; Arjun Rao; Nicholas Cheng; Michael Zhang; Kam Sinn; Amit Kochar; Christine Brabyn; Franz E Babl
Journal:  BMC Pediatr       Date:  2017-06-22       Impact factor: 2.125

5.  Emergency treatment with levetiracetam or phenytoin in status epilepticus in children-the EcLiPSE study: study protocol for a randomised controlled trial.

Authors:  Mark D Lyttle; Carrol Gamble; Shrouk Messahel; Helen Hickey; Anand Iyer; Kerry Woolfall; Amy Humphreys; Naomi E A Bacon; Louise Roper; Franz E Babl; Stuart R Dalziel; Mary Ryan; Richard E Appleton
Journal:  Trials       Date:  2017-06-19       Impact factor: 2.279

6.  Sodium valproate compared to phenytoin in treatment of status epilepticus.

Authors:  Mohammad Reza Amiri-Nikpour; Surena Nazarbaghi; Parisa Eftekhari; Sedra Mohammadi; Sina Dindarian; Mahdi Bagheri; Hozan Mohammadi
Journal:  Brain Behav       Date:  2018-03-23       Impact factor: 2.708
  6 in total

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