| Literature DB >> 19086885 |
Keiichiro Motohashi1, Ji-Hwan Hwang, Yoshitaka Sekido, Motoki Takagi, Kazuo Shin-ya.
Abstract
The screening for active compounds against malignant pleural mesothelioma (MPM) cells produced by Streptomyces sp. AK-AB27 resulted in the isolation of two compounds with a dodecahydrodibenzo[b,d]furan skeleton named JBIR-23 (1) and -24 (2). Their structures were established on the basis of extensive NMR and MS analyses. Compounds 1 and 2 exhibited cytotoxic effects against several MPM cell lines.Entities:
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Year: 2009 PMID： 19086885 DOI： 10.1021/ol802611w
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005