Tuomas Klockars1, Eero Sihvo, Antti Mäkitie. 1. Department of Otorhinolaryngology, Kymenlaakso Central Hospital, Kotka, Finland. tuomas.klockars@fimnet.fi
Abstract
CONCLUSION: The aetiology of Zenker's diverticulum is likely to be multifactorial. The geographical and racial variation in the prevalence and the rare familial cases suggest that genetic predisposition might have a role in the pathogenesis. The mode of inheritance in the rare possible familial cases seems to be autosomal dominant; recessive inheritance is non-existent or extremely rare. OBJECTIVES: To study the inheritance of Zenker's diverticulum. SUBJECTS AND METHODS: A detailed questionnaire concerning physical health and family history was sent to 122 patients with Zenker's diverticulum. RESULTS: The prevalence of familial disease in Finland was found to be < 2%. We found no evidence for genetic founder effect.
CONCLUSION: The aetiology of Zenker's diverticulum is likely to be multifactorial. The geographical and racial variation in the prevalence and the rare familial cases suggest that genetic predisposition might have a role in the pathogenesis. The mode of inheritance in the rare possible familial cases seems to be autosomal dominant; recessive inheritance is non-existent or extremely rare. OBJECTIVES: To study the inheritance of Zenker's diverticulum. SUBJECTS AND METHODS: A detailed questionnaire concerning physical health and family history was sent to 122 patients with Zenker's diverticulum. RESULTS: The prevalence of familial disease in Finland was found to be < 2%. We found no evidence for genetic founder effect.
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