Literature DB >> 19085994

Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing.

Philippe G Nantermet1, Hemaka A Rajapakse, Mathew G Stanton, Shaun R Stauffer, James C Barrow, Allison R Gregro, Keith P Moore, Melissa A Steinbeiser, John Swestock, Harold G Selnick, Samuel L Graham, Georgia B McGaughey, Dennis Colussi, Ming-Tain Lai, Sethu Sankaranarayanan, Adam J Simon, Sanjeev Munshi, Jacquelynn J Cook, Marie A Holahan, Maria S Michener, Joseph P Vacca.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19085994     DOI： 10.1002/cmdc.200800308

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


× No keyword cloud information.
  3 in total

1.  Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound.

Authors:  Jacquelynn J Cook; Kristin R Wildsmith; David B Gilberto; Marie A Holahan; Gene G Kinney; Parker D Mathers; Maria S Michener; Eric A Price; Mark S Shearman; Adam J Simon; Jennifer X Wang; Guoxin Wu; Kevin E Yarasheski; Randall J Bateman
Journal:  J Neurosci       Date:  2010-05-12       Impact factor: 6.167

Review 2.  The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors.

Authors:  Stefania Butini; Simone Brogi; Ettore Novellino; Giuseppe Campiani; Arun K Ghosh; Margherita Brindisi; Sandra Gemma
Journal:  Curr Top Med Chem       Date:  2013       Impact factor: 3.295

Review 3.  BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease.

Authors:  Arun K Ghosh; Heather L Osswald
Journal:  Chem Soc Rev       Date:  2014-10-07       Impact factor: 54.564
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.