Literature DB >> 19085566

Altered pulmonary interleukin-6 signaling in preterm infants developing bronchopulmonary dysplasia.

Philipp von Bismarck1, Andreas Claass, Carsten Schickor, Martin F Krause, Stefan Rose-John.   

Abstract

Interleukin (IL)-6 signaling depends on the soluble IL-6 receptor (sIL-6R) and the soluble glycoprotein 130 (sgp130). To investigate the impact of IL-6 signaling on the pathogenesis of bronchopulmonary dysplasia of prematurity (BPD), IL-6, sIL-6R, and sgp130 were measured by enzyme-linked immunosorbent assay (ELISA) technique in tracheal aspirates of mechanically ventilated preterm infants. Infants developing BPD showed increased concentrations of IL-6, sIL-6R, and sgp-130 in their first week of life. These infants also had significantly higher molar ratios for IL-6/sIL-6R and IL-6/sgp130. The authors conclude that altered interleukin-6 signaling via the soluble receptors sIL-6R and sgp130 may play an important role in pulmonary inflammation of preterm infants.

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Year:  2008        PMID： 19085566     DOI： 10.1080/01902140802389693

Source DB:  PubMed          Journal:  Exp Lung Res        ISSN： 0190-2148            Impact factor:   2.459


  9 in total

1.  IL-6 trans-signaling system in intra-amniotic inflammation, preterm birth, and preterm premature rupture of the membranes.

Authors:  Sarah Y Lee; Irina A Buhimschi; Antonette T Dulay; Unzila A Ali; Guomao Zhao; Sonya S Abdel-Razeq; Mert O Bahtiyar; Stephen F Thung; Edmund F Funai; Catalin S Buhimschi
Journal:  J Immunol       Date:  2011-01-31       Impact factor: 5.422

Review 2.  Targeting inflammation to prevent bronchopulmonary dysplasia: can new insights be translated into therapies?

Authors:  Clyde J Wright; Haresh Kirpalani
Journal:  Pediatrics       Date:  2011-06-06       Impact factor: 7.124

Review 3.  gp130 at the nexus of inflammation, autoimmunity, and cancer.

Authors:  J S Silver; C A Hunter
Journal:  J Leukoc Biol       Date:  2010-07-07       Impact factor: 4.962

4.  A translational cellular model to study the impact of high-frequency oscillatory ventilation on human epithelial cell function.

Authors:  Anja Mowes; Beatriz E de Jongh; Timothy Cox; Yan Zhu; Thomas H Shaffer
Journal:  J Appl Physiol (1985)       Date:  2016-11-10

5.  Neonatal T-cell maturation and homing receptor responses to Toll-like receptor ligands differ from those of adult naive T cells: relationship to prematurity.

Authors:  Maricruz Crespo; Denise G Martinez; Adam Cerissi; Brenda Rivera-Reyes; Helene B Bernstein; Michael M Lederman; Scott F Sieg; Angel A Luciano
Journal:  Pediatr Res       Date:  2011-12-21       Impact factor: 3.756

6.  Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia.

Authors:  Dharmesh Hirani; Cristina M Alvira; Soula Danopoulos; Carlos Milla; Michele Donato; Lu Tian; Jasmine Mohr; Katharina Dinger; Christina Vohlen; Jaco Selle; Silke V Koningsbruggen-Rietschel; Verena Barbarino; Christian Pallasch; Stefan Rose-John; Margarete Odenthal; Gloria S Pryhuber; Siavash Mansouri; Rajkumar Savai; Werner Seeger; Purvesh Khatri; Denise Al Alam; Jörg Dötsch; Miguel A Alejandre Alcazar
Journal:  Eur Respir J       Date:  2022-02-17       Impact factor: 33.795

7.  IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality.

Authors:  Hong Zhang; Patrick Neuhöfer; Liang Song; Björn Rabe; Marina Lesina; Magdalena U Kurkowski; Matthias Treiber; Thomas Wartmann; Sara Regnér; Henrik Thorlacius; Dieter Saur; Gregor Weirich; Akihiko Yoshimura; Walter Halangk; Joseph P Mizgerd; Roland M Schmid; Stefan Rose-John; Hana Algül
Journal:  J Clin Invest       Date:  2013-02-15       Impact factor: 14.808

8.  A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia.

Authors:  Johanna M Huusko; Minna K Karjalainen; Mari Mahlman; Ritva Haataja; M Anneli Kari; Sture Andersson; Gergely Toldi; Outi Tammela; Mika Rämet; Pascal M Lavoie; Mikko Hallman
Journal:  BMC Med Genet       Date:  2014-11-01       Impact factor: 2.103

Review 9.  Hyperoxia-induced bronchopulmonary dysplasia: better models for better therapies.

Authors:  Kiersten Giusto; Heather Wanczyk; Todd Jensen; Christine Finck
Journal:  Dis Model Mech       Date:  2021-02-23       Impact factor: 5.758
  9 in total

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