Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Effect of MT1-MMP deficiency and overexpression in corneal keratocytes on vascular endothelial cell migration and proliferation.

Literature DB >> 19085378

Effect of MT1-MMP deficiency and overexpression in corneal keratocytes on vascular endothelial cell migration and proliferation.

Dimitri T Azar¹, Fabio H Casanova, Tatsuya Mimura, Sandeep Jain, Jin-Hong Chang.

Abstract

PURPOSE: To determine the effect of keratocyte-derived MT1-MMP on calf pulmonary artery endothelial cell (CPAE) proliferation and migration.
METHODS: Keratocyte lines were generated from MT1-MMP knockout (KO) and wild type (WT) mice. WT keratocytes were transfected with WT or mutant MT1-MMP DNAs (DeltaTC or E240A). The effect of keratocyte-conditioned media on CPAE proliferation and migration was assayed.
RESULTS: KO keratocyte conditioned media resulted in the greatest increase of CPAE cell proliferation (190.5+/-6.0%; p<0.01). WT keratocyte conditioned media showed higher CPAE proliferation (155.4+/-3.6%) than WT/MT1-MMP-transfected keratocytes (119.7+/-2.2%; p<0.001). Migration assays confirmed these findings.
CONCLUSIONS: Keratocyte-derived MT1-MMP has anti-angiogenic effects in CPAE cells.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2008 PMID： 19085378 PMCID： PMC2693934 DOI： 10.1080/02713680802461106

Source DB: PubMed Journal: Curr Eye Res ISSN： 0271-3683 Impact factor: 2.424

24 in total

1. Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin.

Authors: C L Wilson; K J Heppner; P A Labosky; B L Hogan; L M Matrisian
Journal: Proc Natl Acad Sci U S A Date: 1997-02-18 Impact factor: 11.205

2. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes.

Authors: T H Vu; J M Shipley; G Bergers; J E Berger; J A Helms; D Hanahan; S D Shapiro; R M Senior; Z Werb
Journal: Cell Date: 1998-05-01 Impact factor: 41.582

3. Functional characterization of neostatins, the MMP-derived, enzymatic cleavage products of type XVIII collagen.

Authors: Jin-Hong Chang; Joel A D Javier; Gene-Yuan Chang; Hailton B Oliveira; Dimitri T Azar
Journal: FEBS Lett Date: 2005-07-04 Impact factor: 4.124

4. Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction.

Authors: J S Mudgett; N I Hutchinson; N A Chartrain; A J Forsyth; J McDonnell; I I Singer; E K Bayne; J Flanagan; D Kawka; C F Shen; K Stevens; H Chen; M Trumbauer; D M Visco
Journal: Arthritis Rheum Date: 1998-01

5. Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.

Authors: T Itoh; M Tanioka; H Yoshida; T Yoshioka; H Nishimoto; S Itohara
Journal: Cancer Res Date: 1998-03-01 Impact factor: 12.701

6. Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis).

Authors: Dimitri T Azar
Journal: Trans Am Ophthalmol Soc Date: 2006

7. Sphingosine-1-phosphate induces the association of membrane-type 1 matrix metalloproteinase with p130Cas in endothelial cells.

Authors: Denis Gingras; Marisol Michaud; Geneviève Di Tomasso; Eric Béliveau; Carine Nyalendo; Richard Béliveau
Journal: FEBS Lett Date: 2007-12-28 Impact factor: 4.124

8. Pro-MMP-2 activation by the PPARgamma agonist, ciglitazone, induces cell invasion through the generation of ROS and the activation of ERK.

Authors: Kyu-Han Kim; Yee Sook Cho; Jong-Min Park; Sang-Oh Yoon; Kyu-Won Kim; An-Sik Chung
Journal: FEBS Lett Date: 2007-06-19 Impact factor: 4.124

9. Comparison of EphA receptor tyrosine kinases and ephrinA ligand expression to EphB-ephrinB in vascularized corneas.

Authors: Takashi Kojima; Tae-Young Chung; Jin-Hong Chang; Rony Sayegh; Fabio H Casanova; Dimitri T Azar
Journal: Cornea Date: 2007-06 Impact factor: 2.651

10. MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover.

Authors: K Holmbeck; P Bianco; J Caterina; S Yamada; M Kromer; S A Kuznetsov; M Mankani; P G Robey; A R Poole; I Pidoux; J M Ward; H Birkedal-Hansen
Journal: Cell Date: 1999-10-01 Impact factor: 41.582

11 in total

1. Corneal epithelial MT1-MMP inhibits vascular endothelial cell proliferation and migration.

Authors: Dimitri T Azar; Fabio H Casanova; Tatsuya Mimura; Sandeep Jain; Zhongjun Zhou; Kyu Yeon Han; Jin-Hong Chang
Journal: Cornea Date: 2010-03 Impact factor: 2.651

Review 2. Wound healing fibroblasts modulate corneal angiogenic privilege: interplay of basic fibroblast growth factor and matrix metalloproteinases in corneal angiogenesis.

Authors: Jin-Hong Chang; Kyu Yeon Han; Dimitri T Azar
Journal: Jpn J Ophthalmol Date: 2010-06-25 Impact factor: 2.447

Review 3. Corneal neovascularization and the utility of topical VEGF inhibition: ranibizumab (Lucentis) vs bevacizumab (Avastin).

Authors: William Stevenson; Sheng-Fu Cheng; Mohammad H Dastjerdi; Giulio Ferrari; Reza Dana
Journal: Ocul Surf Date: 2012-01-25 Impact factor: 5.033

4. MMP-7 knock-in corneal fibroblast cell lines secrete MMP-7 with proteolytic activity towards collagen XVIII.

Authors: Shu-I Yeh; Kyu-Yeon Han; Abdellah Sabri; Mark I Rosenblatt; Dimitri T Azar; Sandeep Jain; Jin-Hong Chang
Journal: Curr Eye Res Date: 2010-09 Impact factor: 2.424

5. MT1-MMP modulates bFGF-induced VEGF-A expression in corneal fibroblasts.

Authors: Kyu-Yeon Han; Daoud C Fahd; Makambo Tshionyi; Norma Allemann; Sandeep Jain; Jin-Hong Chang; Dimitri T Azar
Journal: Protein Pept Lett Date: 2012-12 Impact factor: 1.890

6. Membrane type-1 matrix metalloproteinase potentiates basic fibroblast growth factor-induced corneal neovascularization.

Authors: Tatsuya Onguchi; Kyu Yeon Han; Jin-Hong Chang; Dimitri T Azar
Journal: Am J Pathol Date: 2009-03-05 Impact factor: 4.307