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Literature DB >> 19085123

Macromolecular delivery across the blood-brain barrier.

Abstract

The delivery of macromolecules into the central nervous system (CNS) via the blood stream is seriously limited by the blood-brain barrier (BBB). Noninvasive, transient, and local image-guided blood-brain barrier disruption (BBBD) can be accomplished using focused ultrasound exposure with intravascular injection of pre-formed microbubbles. A detailed description of the method for MRI-guided focal BBBD in animals will be described in this chapter. The method may open a new era in CNS macromolecular drug delivery.

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Year: 2009 PMID： 19085123 DOI： 10.1007/978-1-59745-429-2_13

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

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Cited

7 in total

1. Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions.

Authors: Natalya Rapoport; Kweon-Ho Nam; Roohi Gupta; Zhongao Gao; Praveena Mohan; Allison Payne; Nick Todd; Xin Liu; Taeho Kim; Jill Shea; Courtney Scaife; Dennis L Parker; Eun-Kee Jeong; Anne M Kennedy
Journal: J Control Release Date: 2011-01-26 Impact factor: 9.776

7. Doxorubicin as a molecular nanotheranostic agent: effect of doxorubicin encapsulation in micelles or nanoemulsions on the ultrasound-mediated intracellular delivery and nuclear trafficking.

Authors: Praveena Mohan; Natalya Rapoport
Journal: Mol Pharm Date: 2010-10-27 Impact factor: 4.939

7 in total

Macromolecular delivery across the blood-brain barrier.

1. Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions.

Review 2. Macromolecular drug delivery: basic principles and therapeutic applications.

3. Production of uniformly sized serum albumin and dextrose microbubbles.

4. Focused Ultrasound: An Emerging Therapeutic Modality for Neurologic Disease.

Review 5. Ultrasound-based triggered drug delivery to tumors.

Review 6. Targeted drug delivery across the blood-brain barrier using ultrasound technique.

7. Doxorubicin as a molecular nanotheranostic agent: effect of doxorubicin encapsulation in micelles or nanoemulsions on the ultrasound-mediated intracellular delivery and nuclear trafficking.