Literature DB >> 19085113

Frequency of FLT3 mutations in childhood acute lymphoblastic leukemia.

M Braoudaki1, M Karpusas, K Katsibardi, Ch Papathanassiou, K Karamolegou, F Tzortzatou-Stathopoulou.   

Abstract

FLT3 mutations are occasionally observed in acute lymphoblastic leukemia (ALL). These most frequently manifest as internal tandem duplications (ITD) and activation loop (AL) mutations. This study investigated the incidence of FLT3 mutations in 86 pediatric patients diagnosed with ALL and the co-presence of common RAS mutations. A 2.3% (2/86) FLT3/AL mutation rate in terms of total ALL cases and a 22% (2/9) incidence in hyperdiploid cases was observed. This is in accordance to previous studies indicating a higher incidence in the patient subgroup associated with hyperdiploidy.

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Year:  2008        PMID： 19085113     DOI： 10.1007/s12032-008-9146-z

Source DB:  PubMed          Journal:  Med Oncol        ISSN： 1357-0560            Impact factor:   3.064


  16 in total

1.  Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia.

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Journal:  Br J Haematol       Date:  2001-06       Impact factor: 6.998

2.  Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho).

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Journal:  Leukemia       Date:  1997-09       Impact factor: 11.528

3.  Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia.

Authors:  H Kiyoi; T Naoe; Y Nakano; S Yokota; S Minami; S Miyawaki; N Asou; K Kuriyama; I Jinnai; C Shimazaki; H Akiyama; K Saito; H Oh; T Motoji; E Omoto; H Saito; R Ohno; R Ueda
Journal:  Blood       Date:  1999-05-01       Impact factor: 22.113

4.  Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.

Authors:  Y Yamamoto; H Kiyoi; Y Nakano; R Suzuki; Y Kodera; S Miyawaki; N Asou; K Kuriyama; F Yagasaki; C Shimazaki; H Akiyama; K Saito; M Nishimura; T Motoji; K Shinagawa; A Takeshita; H Saito; R Ueda; R Ohno; T Naoe
Journal:  Blood       Date:  2001-04-15       Impact factor: 22.113

5.  Frequency of RAS gene mutation and its cooperative genetic events in Southeast Asian adult acute myeloid leukemia.

Authors:  Chirayu U Auewarakul; Darat Lauhakirti; Chintana Tocharoentanaphol
Journal:  Eur J Haematol       Date:  2006-03-27       Impact factor: 2.997

6.  K-Ras mutations and N-Ras mutations in childhood acute leukemias with or without mixed-lineage leukemia gene rearrangements.

Authors:  Der-Cherng Liang; Lee-Yung Shih; Jen-Fen Fu; Huei-Ying Li; Hsiu-I Wang; Iou-Jih Hung; Chao-Ping Yang; Tang-Her Jaing; Shu-Huey Chen; Hsi-Che Liu
Journal:  Cancer       Date:  2006-02-15       Impact factor: 6.860

7.  Internal tandem duplication of the flt3 gene found in acute myeloid leukemia.

Authors:  M Nakao; S Yokota; T Iwai; H Kaneko; S Horiike; K Kashima; Y Sonoda; T Fujimoto; S Misawa
Journal:  Leukemia       Date:  1996-12       Impact factor: 11.528

Review 8.  The roles of FLT3 in hematopoiesis and leukemia.

Authors:  D Gary Gilliland; James D Griffin
Journal:  Blood       Date:  2002-09-01       Impact factor: 22.113

9.  FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression.

Authors:  Patrick Brown; Mark Levis; Sheila Shurtleff; Dario Campana; James Downing; Donald Small
Journal:  Blood       Date:  2004-09-16       Impact factor: 22.113

10.  Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.

Authors:  Kajsa Paulsson; Andrea Horvat; Bodil Strömbeck; Fredrik Nilsson; Jesper Heldrup; Mikael Behrendtz; Erik Forestier; Anna Andersson; Thoas Fioretos; Bertil Johansson
Journal:  Genes Chromosomes Cancer       Date:  2008-01       Impact factor: 5.006
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  8 in total

1.  Duplication of Philadelphia chromosome and trisomy of chromosome 21 in a pediatric patient with acute lymphoblastic leukemia.

Authors:  Katerina Katsibardi; Maria Braoudaki; Stefanos I Papadhimitriou; Kalliopi Karamolegou; Fotini Tzortzatou-Stathopoulou
Journal:  Med Oncol       Date:  2010-10-07       Impact factor: 3.064

2.  FLT3 mutation incidence and timing of origin in a population case series of pediatric leukemia.

Authors:  Patrick Chang; Michelle Kang; Anny Xiao; Jeffrey Chang; James Feusner; Patricia Buffler; Joseph Wiemels
Journal:  BMC Cancer       Date:  2010-09-27       Impact factor: 4.430

3.  Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition.

Authors:  Julie Irving; Elizabeth Matheson; Lynne Minto; Helen Blair; Marian Case; Christina Halsey; Isabella Swidenbank; Frida Ponthan; Renate Kirschner-Schwabe; Stefanie Groeneveld-Krentz; Jana Hof; James Allan; Christine Harrison; Josef Vormoor; Arend von Stackelberg; Cornelia Eckert
Journal:  Blood       Date:  2014-09-24       Impact factor: 22.113

4.  The frequency of NPM1 mutations in childhood acute myeloid leukemia.

Authors:  Maria Braoudaki; Chrissa Papathanassiou; Katerina Katsibardi; Natalia Tourkadoni; Kalliopi Karamolegou; Fotini Tzortzatou-Stathopoulou
Journal:  J Hematol Oncol       Date:  2010-10-27       Impact factor: 17.388

5.  FLT3 Internal Tandem Duplication and D835 Mutations in Patients with Acute Lymphoblastic Leukemia and its Clinical Significance.

Authors:  Ghaleb Elyamany; Mohammed Awad; Omar Alsuhaibani; Kamal Fadalla; Omer Al Sharif; Mohammad Al Shahrani; Fahad Alabbas; Abdulaziz Al-Abulaaly
Journal:  Mediterr J Hematol Infect Dis       Date:  2014-06-01       Impact factor: 2.576

6.  Pattern of chromosome involvement in childhood hyperdiploid pre-B-cell acute lymhoblastic leukemia cases from India.

Authors:  Lily S Kerketta; Vundinti Baburao; Kanjaksha Ghosh
Journal:  Indian J Hum Genet       Date:  2014-01

7.  FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia.

Authors:  Albert Català; Marçal Pastor-Anglada; Liska Caviedes-Cárdenas; Roberta Malatesta; Susana Rives; Nerea Vega-García; Mireia Camós; Paula Fernández-Calotti
Journal:  Oncotarget       Date:  2016-08-02

Review 8.  Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic Targeting.

Authors:  Thomas Knight; Julie Anne Elizabeth Irving
Journal:  Front Oncol       Date:  2014-06-24       Impact factor: 6.244
  8 in total

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