| Literature DB >> 19084825 |
Ernestas Gaidamauskas1, Eugenijus Norkus, Eugenijus Butkus, Debbie C Crans, Giedre Grinciene.
Abstract
Variable pH (13)C NMR and (1)H NMR spectroscopic studies of the beta-cyclodextrin (beta-CD) in alkaline aqueous solutions revealed that beta-CD does not deprotonate at pH<12.0. Further increase in solution pH results in the deprotonation of OH-groups adjacent to C-2 and C-3 carbon atoms of beta-CD glucopyranose units, whereas the deprotonation of OH-groups adjacent to C-6 carbon atoms is expressed less markedly. The pK(a) values for beta-CD OH-groups adjacent to C-2 and C-3 carbon atoms are rather close, pK(a1,2) being 13.5+/-0.2 (22.5 degrees C).Entities:
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Year: 2008 PMID： 19084825 DOI： 10.1016/j.carres.2008.10.025
Source DB: PubMed Journal: Carbohydr Res ISSN： 0008-6215 Impact factor: 2.104