| Literature DB >> 19084395 |
Amal Wahhab1, David Smil, Alain Ajamian, Martin Allan, Yves Chantigny, Eric Therrien, Natalie Nguyen, Sukhdev Manku, Silvana Leit, Jubrail Rahil, Andrea J Petschner, Ai-Hua Lu, Alina Nicolescu, Sylvain Lefebvre, Samuel Montcalm, Marielle Fournel, Theresa P Yan, Zuomei Li, Jeffrey M Besterman, Robert Déziel.
Abstract
The sulfamide moiety has been utilized to design novel HDAC inhibitors. The potency and selectivity of these inhibitors were influenced both by the nature of the scaffold, and the capping group. Linear long-chain-based analogs were primarily HDAC6-selective, while analogs based on the lysine scaffold resulted in potent HDAC1 and HDAC6 inhibitors.Entities:
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Year: 2008 PMID： 19084395 DOI： 10.1016/j.bmcl.2008.11.081
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823