BACKGROUND: Intramyocardial fat deposition occurs as an age-related process and in multiple pathologic processes. OBJECTIVE: We evaluated the presence of left ventricular (LV) and right ventricular (RV) intramyocardial fat with 64-slice multidetector computed tomography (MDCT). METHODS: One hundred persons with no history of coronary artery disease (47 women, 53 men; mean age [+/- SD], 53 +/- 12.2 years) and 25 patients with CT findings of myocardial infarction (17 men, 8 women; mean age, 71.3 +/- 9.6 years) were studied for intramyocardial fat in defined segments of the ventricles (17 LV and 10 RV segments) at 3 levels. Fat deposition was defined as density range of -30 to -190 Hounsfield units on images both before and after contrast. RESULTS: In healthy persons, LV intramyocardial fat was primarily located in the basal segments (5% anteroseptal, 5% inferior), and RV intramyocardial fat was primarily located in the anterolateral (24% of base, 23% of mid) and inferolateral (27% base, 27% mid) segments. Older age was associated with an increased odds of RV (sex-adjusted odds ratio [OR] per decade increment, 1.61; 95% confidence interval [CI], 1.11-2.33; P = 0.012) but not LV (OR, 0.97; 95% CI, 0.67-1.40; P = 0.85) intramyocardial fat. Compared with women, men had a lower risk of LV (95% CI, 0.1-0.64; P = 0.004) but not RV (95% CI, 0.35-1.87; P = 0.62) intramyocardial fat. Patients with old myocardial infarction (>3 years) had increased percentage of fat in infarcted left ventricles at all 3 levels (P <or= 0.004). CONCLUSIONS: Intramyocardial fat can be detected by MDCT and is common in healthy and infarcted myocardium.
BACKGROUND: Intramyocardial fat deposition occurs as an age-related process and in multiple pathologic processes. OBJECTIVE: We evaluated the presence of left ventricular (LV) and right ventricular (RV) intramyocardial fat with 64-slice multidetector computed tomography (MDCT). METHODS: One hundred persons with no history of coronary artery disease (47 women, 53 men; mean age [+/- SD], 53 +/- 12.2 years) and 25 patients with CT findings of myocardial infarction (17 men, 8 women; mean age, 71.3 +/- 9.6 years) were studied for intramyocardial fat in defined segments of the ventricles (17 LV and 10 RV segments) at 3 levels. Fat deposition was defined as density range of -30 to -190 Hounsfield units on images both before and after contrast. RESULTS: In healthy persons, LV intramyocardial fat was primarily located in the basal segments (5% anteroseptal, 5% inferior), and RV intramyocardial fat was primarily located in the anterolateral (24% of base, 23% of mid) and inferolateral (27% base, 27% mid) segments. Older age was associated with an increased odds of RV (sex-adjusted odds ratio [OR] per decade increment, 1.61; 95% confidence interval [CI], 1.11-2.33; P = 0.012) but not LV (OR, 0.97; 95% CI, 0.67-1.40; P = 0.85) intramyocardial fat. Compared with women, men had a lower risk of LV (95% CI, 0.1-0.64; P = 0.004) but not RV (95% CI, 0.35-1.87; P = 0.62) intramyocardial fat. Patients with old myocardial infarction (>3 years) had increased percentage of fat in infarcted left ventricles at all 3 levels (P <or= 0.004). CONCLUSIONS: Intramyocardial fat can be detected by MDCT and is common in healthy and infarcted myocardium.
Authors: Neda Rastegar; Jeremy R Burt; Celia P Corona-Villalobos; Anneline S Te Riele; Cynthia A James; Brittney Murray; Hugh Calkins; Harikrishna Tandri; David A Bluemke; Stefan L Zimmerman; Ihab R Kamel Journal: Radiographics Date: 2014-10 Impact factor: 5.333
Authors: Anna S Bader; Jeffrey M Levsky; Benjamin A Zalta; Anna Shmukler; Arash Gohari; Vineet R Jain; Victoria Chernyak; Michael Lovihayeem; Eran Y Bellin; Linda B Haramati Journal: Eur Radiol Date: 2018-06-14 Impact factor: 5.315
Authors: Eric Sung; Adityo Prakosa; Konstantinos N Aronis; Shijie Zhou; Stefan L Zimmerman; Harikrishna Tandri; Saman Nazarian; Ronald D Berger; Jonathan Chrispin; Natalia A Trayanova Journal: Circ Arrhythm Electrophysiol Date: 2020-11-16
Authors: Usama A Daimee; Eric Sung; Marc Engels; Marc K Halushka; Ronald D Berger; Natalia A Trayanova; Katherine C Wu; Jonathan Chrispin Journal: Heart Rhythm O2 Date: 2022-04-02