Literature DB >> 19082805

How to connect the gap between clinical trials and clinical practice.

Hong-cai SHANG1, Hong-juan XU, Jing CHEN, Bo-li ZHANG, You-ping Li, Mike J Clarke.   

Abstract

Clinical research methods have been rapidly developing, and the design of clinical trials including traditional Chinese medicine is advancing. To a certain extent, all of these ensure that the results of clinical research are objective and scientific, but whether these results and the resulting guidelines or consensus have much practical significance on clinical practice is still controversial. The authors engage in both clinical practice and clinical research; they strongly feel that it is necessary to discuss the relationship between clinical trials and clinical practice. This essay discusses this relationship in four parts.

Mesh:

Year:  2008        PMID: 19082805     DOI: 10.1007/s11655-008-0309-8

Source DB:  PubMed          Journal:  Chin J Integr Med        ISSN: 1672-0415            Impact factor:   1.978


  9 in total

1.  Gap between clinical trials and clinical practice: lessons from the Bypass Angioplasty Revascularization Investigation (BARI).

Authors:  Robert L Frye; Maria Mori Brooks; Richard W Nesto
Journal:  Circulation       Date:  2003-04-15       Impact factor: 29.690

2.  External validity of randomised controlled trials: "to whom do the results of this trial apply?".

Authors:  Peter M Rothwell
Journal:  Lancet       Date:  2005 Jan 1-7       Impact factor: 79.321

3.  Can evidence-based guidelines and clinical trials tell us how to treat patients?

Authors:  Jacqueline A French
Journal:  Epilepsia       Date:  2007-05-23       Impact factor: 5.864

4.  External validity of clinical trials in acute myocardial infarction.

Authors:  Philippe Gabriel Steg; José López-Sendón; Esteban Lopez de Sa; Shaun G Goodman; Joel M Gore; Frederick A Anderson; Dominique Himbert; Jeanna Allegrone; Frans Van de Werf
Journal:  Arch Intern Med       Date:  2007-01-08

5.  Stroke units in their natural habitat: can results of randomized trials be reproduced in routine clinical practice? Riks-Stroke Collaboration.

Authors:  B Stegmayr; K Asplund; K Hulter-Asberg; B Norrving; M Peltonen; A Terént; P O Wester
Journal:  Stroke       Date:  1999-04       Impact factor: 7.914

Review 6.  Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysis.

Authors:  George Krasopoulos; Stephanie J Brister; W Scott Beattie; Michael R Buchanan
Journal:  BMJ       Date:  2008-01-17

Review 7.  Internal and external validity of cluster randomised trials: systematic review of recent trials.

Authors:  Sandra Eldridge; Deborah Ashby; Catherine Bennett; Melanie Wakelin; Gene Feder
Journal:  BMJ       Date:  2008-03-25

8.  Trial participants need to be more representative of patients.

Authors:  Bob Roehr
Journal:  BMJ       Date:  2008-04-05

9.  Circular instead of hierarchical: methodological principles for the evaluation of complex interventions.

Authors:  Harald Walach; Torkel Falkenberg; Vinjar Fønnebø; George Lewith; Wayne B Jonas
Journal:  BMC Med Res Methodol       Date:  2006-06-24       Impact factor: 4.615

  9 in total

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