Literature DB >> 19082421

Discovery of a novel molecule that regulates tumor growth and metastasis.

Chery A Whipple1, Arthur D Lander, Murray Korc.   

Abstract

The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell-derived and host-derived GPC1 play an important role in tumor development and spread. These data suggest that GPC1 may be a valid therapeutic target for pancreatic cancer.

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Year:  2008        PMID： 19082421      PMCID： PMC5848622          DOI： 10.1100/tsw.2008.152

Source DB:  PubMed          Journal:  ScientificWorldJournal        ISSN： 1537-744X


  3 in total

1.  Glypican-1 Promotes Tumorigenesis by Regulating the PTEN/Akt/β-Catenin Signaling Pathway in Esophageal Squamous Cell Carcinoma.

Authors:  Jing Li; Yanjie Chen; Cheng Zhan; Jimin Zhu; Shuqiang Weng; Ling Dong; Taotao Liu; Xizhong Shen
Journal:  Dig Dis Sci       Date:  2019-02-07       Impact factor: 3.199

2.  Inactivation of BACE1 increases expression of endothelial nitric oxide synthase in cerebrovascular endothelium.

Authors:  Tongrong He; Livius V d'Uscio; Ruohan Sun; Anantha Vijay R Santhanam; Zvonimir S Katusic
Journal:  J Cereb Blood Flow Metab       Date:  2022-06-08       Impact factor: 6.960

3.  Identification of a novel glycolysis-related gene signature for predicting metastasis and survival in patients with lung adenocarcinoma.

Authors:  Lei Zhang; Zhe Zhang; Zhenglun Yu
Journal:  J Transl Med       Date:  2019-12-17       Impact factor: 5.531
  3 in total

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