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Literature DB >> 19082005

Controlled-folding of a small molecule modulates DNA G-quadruplex recognition.

Sebastian Müller¹, G Dan Pantoş, Raphaël Rodriguez, Shankar Balasubramanian.

Abstract

Differential recognition of diverse G-quadruplex structures can be achieved by controlling the folding of a small molecule.

Entities: Chemical Gene Species

Mesh：

Substances：
Ligands
Guanine
DNA

Year: 2008 PMID： 19082005 PMCID： PMC2726640 DOI： 10.1039/b816861j

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

18 in total

1. Fluorescence resonance energy transfer as a probe for G-quartet formation by a telomeric repeat.

Authors: J L Mergny; J C Maurizot
Journal: Chembiochem Date: 2001-02-02 Impact factor: 3.164

2. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription.

Authors: Adam Siddiqui-Jain; Cory L Grand; David J Bearss; Laurence H Hurley
Journal: Proc Natl Acad Sci U S A Date: 2002-08-23 Impact factor: 11.205

3. Inhibition of telomerase by G-quartet DNA structures.

Authors: A M Zahler; J R Williamson; T R Cech; D M Prescott
Journal: Nature Date: 1991-04-25 Impact factor: 49.962

4. The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells.

Authors: Dennis Gomez; Marie-Françoise O'Donohue; Thomas Wenner; Céline Douarre; Jérome Macadré; Pascale Koebel; Marie-Josèphe Giraud-Panis; Hervé Kaplan; Alain Kolkes; Kazuo Shin-ya; Jean-François Riou
Journal: Cancer Res Date: 2006-07-15 Impact factor: 12.701

5. Helical molecular programming: supramolecular double helices by dimerization of helical oligopyridine-dicarboxamide strands.

Authors: V Berl; I Huc; R G Khoury; J M Lehn
Journal: Chemistry Date: 2001-07-02 Impact factor: 5.236

Controlled-folding of a small molecule modulates DNA G-quadruplex recognition.

1. Fluorescence resonance energy transfer as a probe for G-quartet formation by a telomeric repeat.

2. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription.

3. Inhibition of telomerase by G-quartet DNA structures.

4. The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells.

5. Helical molecular programming: supramolecular double helices by dimerization of helical oligopyridine-dicarboxamide strands.

6. Aromatic delta-peptides.

7. Putative DNA quadruplex formation within the human c-kit oncogene.

8. Oxazole-based peptide macrocycles: a new class of G-quadruplex binding ligands.

9. A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene.

10. G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.

1. G-quadruplex structures and G-quadruplex-interactive compounds.

2. Small-molecule-mediated G-quadruplex isolation from human cells.

3. Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines.

4. Use of a designed Peptide library to screen for binders to a particular DNA g-quadruplex sequence.

5. Targeting DNA G-quadruplexes with helical small molecules.